The first document below, EPA’s Application of Systematic Review in TSCA Risk Evaluations, will guide the Agency’s selection and review of studies and provide the public with continued transparency regarding how EPA plans to evaluate scientific information. Read the Federal Register notice announcing the availability of this document. EPA's approach to systematic review will be available for comment until August 16, 2018 in docket EPA-HQ-OPPT-2018-0210.

EPA’s initial work on systematic review was described in the supplemental files for each TSCA scope document, which included the Strategy for Conducting Literature Searches and the Bibliography for each chemical. The second document below contains the Agency’s response to the comments received on these supplemental documents.

Learn more about risk evaluations for existing chemicals under TSCA.

• Application of Systematic Review in TSCA Risk Evaluations (PDF)(248 pp, 4 MB)
• Response to Public Comments Related to the Supplemental Files Supporting the TSCA Scope Documents for the First Ten Risk Evaluations (PDF)(10 pp, 174 K)