An official website of the United States government.

This is not the current EPA website. To navigate to the current EPA website, please go to This website is historical material reflecting the EPA website as it existed on January 19, 2021. This website is no longer updated and links to external websites and some internal pages may not work. More information »

Assessing and Managing Chemicals under TSCA

Regulation of Chemicals under Section 6(a) of the Toxic Substances Control Act

On this page:

§ 6 Rules Under Amended TSCA

Final Rules

Rules Under Development

§ 6 Rules Prior to June 2016

Some Section 6 actions have led to ongoing programs relating to chemical substances of national concern, such as asbestos and polychlorinated biphenyls (PCBs). Others – such as acrylamide – were withdrawn when the circumstances that led to the proposal of the rule changed, enabling the risk to be reduced without rulemaking.

  • Polychlorinated biphenyls (PCBs): Manufacturing, Processing, Distribution in Commerce and Use Prohibitions.

    EPA formalized the statutory ban contained in section 6(e) of TSCA in final regulations issued on May 31, 1979, 44 FR 31542. Subsequently, EPA has taken numerous actions to regulate PCB uses and disposal.

  • Metalworking Fluids: Specific Use Requirements for Certain Chemical Substances

    EPA took three actions to limit certain uses of metalworking fluids:

  • Water Treatment Chemicals: Air Conditioning and Cooling Systems
    • Hexavalent chromium-based water treatment chemicals in cooling systems at 40 CFR 749.68
  • Asbestos Worker Protection

    EPA issued asbestos worker protection rules extending the Occupational Safety and Health Administration (OSHA) Asbestos standards in 29 CFR 1910.1001 and 29 CFR 1926.1101 to certain state and local government employees.

  • Prohibition of the Manufacture, Importation, Processing and Distribution in Commerce of Certain Asbestos-Containing Products; Labeling Requirements

    EPA’s ban on existing uses of asbestos, known as the Asbestos Ban and Phaseout Rule, was remanded in the Corrosion Proof Fittings v. EPA case (947 F.2d 1201). Learn more.


Section 6 of the Toxic Substances Control Act (TSCA), as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act, provides EPA with the authority to prohibit or limit the manufacture, processing, distribution in commerce, use, or disposal of a chemical if EPA evaluates the risk and concludes that the chemical presents an unreasonable risk to human health or the environment.

Please Note

On June 22, 2016, the Frank R. Lautenberg Chemical Safety for the 21st Century Act, which updates the Toxic Substances Control Act was signed into law. 

For more information on the risk evaluation and prioritization final rules.

Learn more about the new law, find summary information and read frequently asked questions.

The law authorizes EPA to issue regulations requiring one or more of the following actions to the extent necessary so that the chemical substance no longer presents an unreasonable risk:

  • Prohibit or otherwise restrict manufacture, processing, or distribution in commerce;
  • Prohibit or otherwise restrict for a particular use or above a set concentration;
  • Require minimum warnings and instructions with respect to use, distribution in commerce, or disposal;
  • Require recordkeeping or testing;
  • Prohibit or regulate any manner or method of commercial use;
  • Prohibit or regulate any manner or method of disposal; and/or
  • Direct manufacturers or processors to give notice of the unreasonable risk to distributors and replace or repurchase products if required.

EPA must issue these regulations within specific timelines and in accordance with additional requirements laid out in TSCA section 6(c) (15 U.S.C. §2605).

In addition, EPA is also authorized to regulate under section 6 of TSCA:

  • Chemicals defined under section 6(h) of TSCA.
    • These are certain chemicals that meet the statutory criteria for persistent, bioaccumulative, and toxic chemicals as described in section 6(h) (15 U.S.C. §2605). EPA identified five chemicals meeting these criteria.
    • These chemicals are candidates for regulatory action, with a statutory requirement for a proposed rule no later than 3 years after June 22, 2016.

Read TSCA Section 6 (15 U.S.C. §2605).