An official website of the United States government.

This is not the current EPA website. To navigate to the current EPA website, please go to This website is historical material reflecting the EPA website as it existed on January 19, 2021. This website is no longer updated and links to external websites and some internal pages may not work. More information »

Distributed Structure-Searchable Toxicity (DSSTox) Database

Graphic of Structures and Toxicity Data feeding into DSSTox SDF FilesDSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology. A distinguishing feature of this effort is the accurate mapping of bioassay and physicochemical property data associated with chemical substances to their corresponding chemical structures.  

The DSSTox Database incorporates state-of-the-art cheminformatics workflows, provides the chemical infrastructure for EPA’s Safer Chemicals Research, including the ToxCast and Tox21 high-throughput toxicology efforts.  

EPA will continue to add content to DSSTox and users will be able to directly access the updated and expanded DSSTox database, as well as chemical exploration tools and capabilities currently under development. These capabilities will include chemical searching and SDF file downloads, as well as web-services and dynamic chemical linkages to and from EPA's CompTox Chemicals Dashboard.

Publications and Resources