The SeqAPASS tool has been developed to predict across species relative intrinsic susceptibility to chemicals with known molecular targets (e.g., pharmaceuticals, pesticides) as well as evaluate conservation of molecular targets from high-throughput screening assays (i.e., U.S. Environmental Protection Agency ToxCast Program) and molecular initiating events (MIEs) and early key events in the adverse outcome pathway framework, as a means to extrapolate such knowledge across species. This guide provides information on how to use SeqAPASS version 4.0.

• Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) User Guide (PDF)(81 pp, 9 MB)