Tox21 Work Groups
Assays/Pathways
- Identify key toxicity pathways/assays (with a focus on human cells) and prioritize assays for use at National Center for Advancing Translational Sciences (NCATS)
- Identify methods for incorporating hepatic metabolism into in vitro assays
- Consider approaches for evaluating compound, pathway, and cell-to-cell interactions
Compounds
- Establish library of >10,000 compounds with known structures for testing at the NCATS
- Establish procedures for determining the identity, purity, and stability of each compound
- Future, establish a library of water soluble compounds for testing at the NCATS
- Future, establish a library of mixtures for testing at the NCATS
Bioinformatics Group
- Evaluate response within and across assays/endpoints
- Evaluate patterns of response and relationship to adverse health outcomes in experimental animals and humans
- Make all data publicly accessible (CEBS, PubChem, ACToR)
Targeted Testing Group
- Design studies to evaluate the relevance of prediction models and prioritization schemes developed from Tox21 data