Toxicity Forecasting Human and Rat Assays
The following are lists of human and rat assays used in the Toxicity Forecasting (ToxCast) system. See Overview of ToxCast Assays for more details.
| ToxCast Human Tissue Assays | ||||
|---|---|---|---|---|
| ACEA_T47D APR_HepG2_1hr APR_HepG2_24hr APR_HepG2_72hr ATG_CIS ATG_TRANS BSK_3C BSK_4H BSK_BE3C BSK_CASM3C BSK_hDFCGF BSK_KF3CT BSK_LPS BSK_SAg NVS_ADME_hCYP19A1 NVS_ADME_hCYP1A1 NVS_ADME_hCYP1A2 NVS_ADME_hCYP1B1 NVS_ADME_hCYP2A6 NVS_ADME_hCYP2B6 NVS_ADME_hCYP2C18 NVS_ADME_hCYP2C19 NVS_ADME_hCYP2C8 NVS_ADME_hCYP2C9 NVS_ADME_hCYP2D6 NVS_ADME_hCYP2E1 NVS_ADME_hCYP2J2 NVS_ADME_hCYP3A4 NVS_ADME_hCYP3A5 NVS_ADME_hCYP4F12 NVS_ENZ_hAbl NVS_ENZ_hAChE NVS_ENZ_hACP1 NVS_ENZ_hAKT1 NVS_ENZ_hAKT2 NVS_ENZ_hAKT3 NVS_ENZ_hAMPKa1 NVS_ENZ_hAurA NVS_ENZ_hBACE NVS_ENZ_hBTK NVS_ENZ_hCASP1 NVS_ENZ_hCASP10 NVS_ENZ_hCASP2 NVS_ENZ_hCASP3 NVS_ENZ_hCASP4 NVS_ENZ_hCASP5 NVS_ENZ_hCASP8 NVS_ENZ_hCDK2 NVS_ENZ_hCDK6 NVS_ENZ_hCHK1 |
NVS_ENZ_hCK1a NVS_ENZ_hCK1D NVS_ENZ_hCK2a2b2 NVS_ENZ_hCSF1R NVS_ENZ_hDUSP3 NVS_ENZ_hEGFR NVS_ENZ_hElastase NVS_ENZ_hEphA1 NVS_ENZ_hEphA2 NVS_ENZ_hEphB1 NVS_ENZ_hEphB2 NVS_ENZ_hES NVS_ENZ_hFGFR1 NVS_ENZ_hFGFR3 NVS_ENZ_hFyn NVS_ENZ_hGSK3b NVS_ENZ_hHDAC3 NVS_ENZ_hHDAC6 NVS_ENZ_hIGF1R NVS_ENZ_hIKKa NVS_ENZ_hInsR NVS_ENZ_hIRAK4 NVS_ENZ_hJak2 NVS_ENZ_hJNK2 NVS_ENZ_hLck NVS_ENZ_hLynA NVS_ENZ_hLynB NVS_ENZ_hMAPK1 NVS_ENZ_hMAPK11 NVS_ENZ_hMAPK3 NVS_ENZ_hMAPKAPK2 NVS_ENZ_hMAPKAPK5 NVS_ENZ_hMARK1 NVS_ENZ_hMet NVS_ENZ_hMMP1 NVS_ENZ_hMMP13 NVS_ENZ_hMMP2 NVS_ENZ_hMMP3 NVS_ENZ_hMMP7 NVS_ENZ_hMMP9 NVS_ENZ_hMsk1 NVS_ENZ_hNEK2 NVS_ENZ_hPAK2 NVS_ENZ_hPAK4 NVS_ENZ_hPDE10 NVS_ENZ_hPDE4A1 NVS_ENZ_hPDE5 NVS_ENZ_hPI3Ka NVS_ENZ_hPKA NVS_ENZ_hPKCz |
NVS_ENZ_hPKD2 NVS_ENZ_hPPM1A NVS_ENZ_hPPP1CA NVS_ENZ_hPPP2CA NVS_ENZ_hPTEN NVS_ENZ_hPTPN1 NVS_ENZ_hPTPN11 NVS_ENZ_hPTPN12 NVS_ENZ_hPTPN13 NVS_ENZ_hPTPN14 NVS_ENZ_hPTPN2 NVS_ENZ_hPTPN4 NVS_ENZ_hPTPN6 NVS_ENZ_hPTPN9 NVS_ENZ_hPTPRB NVS_ENZ_hPTPRC NVS_ENZ_hPTPRF NVS_ENZ_hPTPRM NVS_ENZ_hRAF1 NVS_ENZ_hROCK1 NVS_ENZ_hSGK1 NVS_ENZ_hSIRT1 NVS_ENZ_hSIRT2 NVS_ENZ_hSIRT3 NVS_ENZ_hSRC NVS_ENZ_hSyk NVS_ENZ_hTie2 NVS_ENZ_hTrkA NVS_ENZ_hVEGFR1 NVS_ENZ_hVEGFR2 NVS_ENZ_hVEGFR3 NVS_ENZ_hZAP70 NVS_ENZ_hDYRK1a NVS_GPCR_h5HT2A NVS_GPCR_h5HT5A NVS_GPCR_h5HT6 NVS_GPCR_h5HT7 NVS_GPCR_hAdoRA1 NVS_GPCR_hAdoRA2a NVS_GPCR_hAdra2A NVS_GPCR_hAdra2C NVS_GPCR_hAdrb1 NVS_GPCR_hAdrb2 NVS_GPCR_hAdrb3 NVS_GPCR_hAT1 NVS_GPCR_hC5a NVS_GPCR_hDRD1 NVS_GPCR_hDRD2s NVS_GPCR_hDRD4.4 NVS_GPCR_hETA |
NVS_GPCR_hETB NVS_GPCR_hH1 NVS_GPCR_hLTB4_BLT1 NVS_GPCR_hM1 NVS_GPCR_hM2 NVS_GPCR_hM3 NVS_GPCR_hM4 NVS_GPCR_hM5 NVS_GPCR_hNK2 NVS_GPCR_hNPY1 NVS_GPCR_hNPY2 NVS_GPCR_hNTS NVS_GPCR_hOpiate_D1 NVS_GPCR_hOpiate_mu NVS_GPCR_hORL1 NVS_GPCR_hPY2 NVS_GPCR_hTXA2 NVS_GPCR_hV1A NVS_IC_hKhERGCh NVS_LGIC_h5HT3 NVS_LGIC_hNNR_NBungSens NVS_MP_hPBR NVS_NR_hAR NVS_NR_hCAR_Agonist NVS_NR_hCAR_Antagonist NVS_NR_hER NVS_NR_hFXR_Agonist NVS_NR_hFXR_Antagonist NVS_NR_hGR NVS_NR_hPPARa NVS_NR_hPPARg NVS_NR_hPR NVS_NR_hPXR NVS_NR_hRAR_Antagonist NVS_NR_hRARa_Agonist NVS_NR_hTRa_Antagonist NVS_OR_hFKBP12 NVS_TR_hAdoT NVS_TR_hDAT NVS_TR_hNET NVS_TR_hSERT OT_AR_ARSRC1_0480 OT_AR_ARSRC1_0960 OT_ER_ERaERa_0480 OT_ER_ERaERa_1440 OT_ER_ERaERb_0480 OT_ER_ERaERb_1440 OT_ER_ERbERb_0480 OT_ER_ERbERb_1440 OT_ERa_GFPERaERE_0120 |
OT_ERa_GFPERaERE_0480 OT_FXR_FXRSRC1_0480 OT_FXR_FXRSRC1_1440 OT_NURR1_NURR1RXRa_0480 OT_NURR1_NURR1RXRa_1440 OT_PPARg_PPARgSRC1_0480 OT_PPARg_PPARgSRC1_1440 TOX21_AR_BLA_Agonist TOX21_AR_BLA_Antagonist TOX21_AR_LUC_MDAKB2_Agonist TOX21_AR_LUC_MDAKB2_Antagonist TOX21_Aromatase_Inhibition TOX21_AutoFluor_HEK293 TOX21_AutoFluor_HEPG2 TOX21_ELG1_LUC_Agonist TOX21_ERa_BLA_Agonist TOX21_ERa_BLA_Antagonist TOX21_ERa_LUC_BG1_Agonist TOX21_ERa_LUC_BG1_Antagonist TOX21_GR_BLA_Agonist TOX21_GR_BLA_Antagonist TOX21_MMP TOX21_PPARg_BLA_Agonist TOX21_AhR_LUC_Agonist CEETOX_H295R TOX21_ARE_BLA_Agonist TOX21_HSE_BLA_Agonist TOX21_p53_BLA_p1 TOX21_FXR_BLA_Agonist TOX21_FXR_BLA_Antagonist TOX21_PPARd_BLA_Agonist TOX21_PPARd_BLA_Antagonist TOX21_PPARg_BLA_Antagonist TOX21_VDR_BLA_Agonist TOX21_VDR_BLA_Antagonist ATG_XTT_Cytotoxicity CLD_6hr CLD_24hr CLD_48hr TOX21_p53_BLA_p2 TOX21_p53_BLA_p3 TOX21_p53_BLA_p4 TOX21_p53_BLA_p5 TOX21_ESRE_BLA TOX21_NFkB_BLA_Agonist ATG_TRANS2 NCCT_HEK293T_CellTiterGLO ATG_GPCR_TRANS |
| ToxCast Rat Tissue Assays | ||||
|---|---|---|---|---|
| NVS_ADME_rCYP1A1 NVS_ADME_rCYP1A2 NVS_ADME_rCYP2A1 NVS_ADME_rCYP2A2 NVS_ADME_rCYP2B1 NVS_ADME_rCYP2C11 NVS_ADME_rCYP2C12 NVS_ADME_rCYP2C13 NVS_ADME_rCYP2C6 NVS_ADME_rCYP2D1 NVS_ADME_rCYP2D2 NVS_ADME_rCYP2E1 NVS_ADME_rCYP3A1 NVS_ADME_rCYP3A2 NVS_ENZ_rACFSKBinding NVS_ENZ_rAChE NVS_ENZ_rCNOS NVS_ENZ_rCOMT NVS_ENZ_rMAOAC NVS_ENZ_rMAOAP |
NVS_ENZ_rMAOBC NVS_ENZ_rMAOBP NVS_GPCR_r5HT_NonSelective NVS_GPCR_r5HT1_NonSelective NVS_GPCR_rAdra1_NonSelective NVS_GPCR_rAdra1A NVS_GPCR_rAdra1B NVS_GPCR_rAdra2_NonSelective NVS_GPCR_rAdrb_NonSelective NVS_GPCR_rCRF NVS_GPCR_rGABBR NVS_GPCR_rGalanin NVS_GPCR_rGHB NVS_GPCR_rH3 NVS_GPCR_rmAdra2B NVS_GPCR_rmMGluR1 NVS_GPCR_rmMGluR5 NVS_GPCR_rNK1 NVS_GPCR_rNK3 NVS_GPCR_rNTS |
NVS_GPCR_rOpiate_NonSelective NVS_GPCR_rOpiate_NonSelectiveNa NVS_GPCR_rOXT NVS_GPCR_rSST NVS_GPCR_rTRH NVS_GPCR_rV1 NVS_GPCR_rVIP_NonSelective NVS_IC_rCaBTZCHL NVS_IC_rCaChN NVS_IC_rCaDHPRCh_L NVS_IC_rKAR NVS_IC_rKATPCh NVS_IC_rKCaCh NVS_IC_rNaCh_site2 NVS_LGIC_rAMPA NVS_LGIC_rGABAR_NonSelective NVS_LGIC_rGABARa6 NVS_LGIC_rGluNMDA_Agonist NVS_LGIC_rGluNMDA_MK801_Agonist NVS_LGIC_rGlyRStrySens |
NVS_LGIC_rNNR_BungSens NVS_MP_rPBR NVS_NR_rAR NVS_NR_rMR NVS_TR_rAdoT NVS_TR_rNET NVS_TR_rSERT NVS_TR_rVMAT2 TOX21_TR_LUC_GH3_Agonist TOX21_TR_LUC_GH3_Antagonist APR_Hepat_1hr APR_Hepat_24hr APR_Hepat_48hr NHEERL_TPO_AUR |
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