The global rise in metabolic diseases, such as obesity, is of particular concern because of the increased risk associated with life-threatening diseases such as diabetes, cardiovascular disease, and cancer. The possibility that exposure to chemicals in the environment and everyday contact to chemicals in consumer projects can contribute to metabolic syndrome is being studied by EPA and other institutions.

Exploring the role stressors play in childhood obesity 

EPA is completing a state-of-the-science literature review to explore the interrelationships between chemical and non-chemical stressors that may contribute to the childhood obesity epidemic. Researchers are investigating the role of environmental chemicals and the role they plan in contributing to metabolic syndrome through collaborative research efforts at NIEHS/EPA Children's Environmental Health and Disease Prevention Research Centers:

• Perinatal Exposures, Epigenetics, Child Obesity and Sexual Maturation
• Children's Environmental Health and Disease Prevention Research Center: Formative Center

Developing in vitro models to study chemicals effects on obesity

EPA researchers are developing in vitro models that use adipocyte (lipocytes and fat cells) as potential predictors of obesity.

• The Effects of Perfluorinated Chemicals on Adipoctye Differentiation In Vitro