Lowest Concentration Minimum Reporting Level (LCMRL) Calculator
The Lowest Concentration Minimum Reporting Level (LCMRL) is a laboratory and analyte specific quantity.
The LCMRL:
- Considers both accuracy and precision in analytical measurement.
- Is based on linear regression of multiple concentration replicate data and a 99% prediction interval around the regression line.
- Is used primarily during analytical method development, although laboratories may determine LCMRLs as an aid in determining their single-laboratory minimum quantitation level.
Technical Basis for the Lowest Concentration Minimum Reporting Level (LCMRL) Calculator (PDF)(30 pp, 230 K, About PDF)
Lowest Concentration Minimum Reporting Level (LCMRL) Calculator Application (ZIP)(1 pg, 12 MB, December 2010)