Label Review Training: Module 3: Special Issues, Page 27
Section 6: How should I review worker protection labeling?
Determining Restricted Entry Intervals
The correct REI may be specified in the regulatory assessment document. If a regulatory assessment document is not available, refer to Supplement Three-A of Pesticide Registration (PR) Notice 93-7, or use the following guidance to determine the correct REI.
To determine REIs, follow the steps below, but be sure to also check any RED or registration review documents to determine if a specific REI was set on a case-by-case basis for this chemical.
Step 1: Identify acute toxicity data to be used in determining REIs
REIs are based on the most severe acute toxicity category assigned to the acute dermal, eye irritation, and skin irritation data for all of the active ingredients in a product. In many instances, these data are not always available. Refer to Chapter 10, Section VII.C of the Label Review Manual for a list indicating the preferred order for selecting data with which to determine the toxicity category for each active ingredient.
Step 2: Determine appropriate REI(s) using the chart below
|Most Severe Toxicity Category Used to Determine the REI||Length of Required REI|
|If the most severe toxicity category is III or IV...||The REI is 12 hours|
|If the most severe toxicity category is II...||The REI is 24 hours|
|If the most severe toxicity category is I...||The REI is 48 hours|
If the product is an organophosphate ester that inhibits cholinesterase and may be applied outdoors in an area where the average rainfall for the application site is less than 25 inches per year.
|The REI is 72 hours|
For more information about REIs, see Chapter 10, Section VIII of the Label Review Manual or Supplement Three-A of PR Notice 93-7.