This revised science policy emphasizes the weighing of all relevant evidence when selecting endpoints for the hazard assessment of anticholinesterase pesticides. This "weight-of-the-evidence" review, conducted on a case-by-case, chemical-by-chemical basis, is accomplished by performing an integrative analysis after assessing all the individual lines of evidence (including all available data on cholinesterase inhibition in all compartments -- central nervous system, peripheral nervous system, red blood cells, and plasma -- as well as data on clinical signs, symptoms and other physiological or behavioral effects). 

• Cholinesterase Inhibition (PDF)(53 pp, 97 K)