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EPA Amends Registration for Enlist Duo Herbicide to Add GE Cotton and Additional States

For Release: January 12, 2017

Enlist Duo, a formula containing the choline salt of 2,4-D and glyphosate for use in controlling weeds in genetically engineered (GE) crops, was first registered in 2014 for use in GE corn and soybean crops. EPA is amending the registration to include GE cotton and expand the use to an additional 19 states for GE corn, soybean, and cotton and re-affirming our original decision before the remand.

EPA did a comprehensive review for the initial registration of Enlist Duo and now again in response to the application to amend the registration. EPA’s protective and conservative human health and ecological risk assessments re-confirmed our 2014 safety findings. The pesticide meets the safety standard for the public, agricultural workers, and non-target plants and animal species, including a “no effects” determination for species listed as threatened or endangered under the Endangered Species Act.

Enlist Duo is a low-volatility pesticide formulation and includes the following restrictions: No application from aircraft; no application when the wind speed is over 15 mph; buffer zones to protect sensitive areas; and application only with approved nozzles at specified pressures.

Enlist Duo was previously registered for use on GE corn and soybean crops in Arkansas, Illinois, Indiana, Iowa, Kansas, Louisiana, Minnesota, Mississippi, Missouri, Nebraska, North Dakota, Oklahoma, Ohio, South Dakota, and Wisconsin. This final decision to expand the use of Enlist Duo will allow use on GE cotton in those states and extend use on GE corn, soybean and cotton crops to include Alabama, Arizona, Colorado, Delaware, Florida, Georgia, Kentucky, Maryland, Michigan, North Carolina, New Jersey, New Mexico, New York, Pennsylvania, South Carolina, Tennessee, Texas, Virginia, and West Virginia.

To view the final decision document and other related documents, see EPA docket EPA‑HQ‑OPP‑2016‑0594 at

Read more about the Enlist Duo registration.