U.S. Environmental Protection Agency
Office of Research and Development
Science to Achieve Results (STAR) Program

ADVANCING TOXICOKINETICS FOR EFFICIENT AND ROBUST CHEMICAL EVALUATIONS

CLOSED - FOR REFERENCES PURPOSES ONLY

Recipients List

This is the initial announcement of this funding opportunity.

Funding Opportunity Number: EPA-G2019-STAR-D1

Catalog of Federal Domestic Assistance (CFDA) Number: 66.509

Solicitation Opening Date: July 25, 2019
Solicitation Closing Date: September 24, 2019 : 11:59:59 pm Eastern Time

The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications proposing to advance the development of chemical toxicokinetic tools and approaches for broader applicability during chemical evaluations, with an emphasis on their application within new approach methodology (NAM) frameworks. Toxicokinetics describes the absorption, distribution, metabolism, and excretion of chemicals and their metabolites by the body, and as such provides a framework for extrapolating in vivo doses of concern from in vitro-derived concentrations that cause perturbations at the cellular or molecular level. The incorporation of new methods, tools and approaches can simultaneously improve predictivity, reduce uncertainty and build confidence in the successful application of such extrapolations.

For more information, and how to apply, please click on the link provided below.

• ADVANCING TOXICOKINETICS FOR EFFICIENT AND ROBUST CHEMICAL EVALUATIONS (PDF)(45 pp, 530 K, 8/16/2019)
• Informational Webinar Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations Applications Request for Applications (RFA) (8/7/2019)

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