Details

Purpose of the Meeting: The U.S. Environmental Protection Agency, through its Science to Achieve Results (STAR) grant program, is developing in vitro cell cultures models that replicate human biological interactions within complex tissues or organs. Advancements in these microphysiological organotypic cell culture models are increasing the probability that these platforms will reduce and replace animal testing.  These Organotypic Culture Models for Predictive Toxicology (OCM-PTs) will provide toxicity testing alternatives that are more public health relevant, faster, and less costly. Robust models of organs’ and tissues’ responses to environmental chemicals will be critical to informing implementation of the Frank R. Lautenberg Chemical Safety for the 21st Century Act, the recently amended Toxic Substances Control Act.

Sessions will be held with young investigators from the OCM-PT Centers based in the:

• University of Wisconsin (Human Models for Analysis of Pathways Center)
• Vanderbilt University/University of Pittsburgh (the Vanderbilt-Pittsburgh Resource for Organotypic Models for Predictive Toxicology)
• University of Washington (the University of Washington Predictive Toxicology Center)
• Texas A&M/North Carolina State University (the Cardiotoxicity Adverse Outcome Pathway Center)
• Collaborators in the Chemical Safety for Sustainability Program at the US Environmental Protection Agency 

Presentations

Meeting Agenda (PDF) (2 pp, 400 K, 06/13/2017)

Mamosphere Bioreactor for Lifestage Specific Toxicology (PDF) (20pp, 2 MB, 05/18/2017)

Synthetic Hydrogels supporting 3D Mamary Duct Morphogenisis (PDF) (16pp, 3 MB, 05/19/2017)

Utilizing an Adverse Outcome Pathway Based Approach to Identify Readouts and Cellular Components for an Organotypic Breast Model (PDF) (17 pp, 2 MB, 05/19/2017)

Engineering a Human Fusion-competent Organotypic Model of Osteogenesis and Morphogenetic Fusion (PDF) (21 pp, 4 MB, 05/25/2017)

Engineering a Human Microfluidics Platform for Palate Morphogenisis (PDF) (14pp, 2 MB, 05/19/2017)

Stage-specific OCMs to Analyze Teratogen-induced Limb Defects (PDF) (19 pp, 25 MB, 05/18/2017)

Population-based Cardiotoxicity Assessment with Human Stem Cell-derived OCMs (PDF) (11 pp, 4 MB, 05/31/2017)

Synthetic Hydrogel Matrices for Assessing Angiogenesis and Vascular Toxicity (PDF) (63 pp, 10 MB, 05/31/2017)

Engineering a Human Endocardial OCM for Assessing Valvuloseptal Development (PDF) (20 pp, 13 MB, 05/31/2017)

Embryoid Body-based OCM for Cardiotoxicity Screening (PDF) (16 pp, 26 MB, 05/25/2017)

Instrumented Fetal Membrane-on-a-Chip (IFMOC) for Human Inflammatory Pathways (PDF) 16 pp, 2MB, 05/19/2017)

Classification Model of Blood-brain Barrier Development and Toxicity (PDF) (18 pp, 3MB, 05/31/2017)

An Integrated Liver-kidney Platform for Assessing Adverse Outcome Pathways (AOPs) (PDF) (12 pp, 970 K, 05/25/2017)

Agent Based Modeling of Neurovascular Unit development (PDF) (17 pp, 2 MB, 05/31/2017)

These projects are in line with EPA's Chemical Safety for Sustainability (CSS) Research Program. Improving the safe production, use, and disposal of chemicals is a major priority in support of actions to protect human health and the environment. The Agency’s CSS research program provides the decision-support tools needed to meet that priority, while advancing innovative ways to evaluate chemicals, conduct risk management, and prioritize time-critical research.

It is EPA's policy to make reasonable accommodation to persons with disabilities wishing to participate in the agency's programs and activities, pursuant to the Rehabilitation Act of 1973, 29 U.S.C. 791. Any request for accommodation should be made to Barbara Klieforth at Klieforth.Barbara@epa.gov or 202-564-7723.