The 1986 Guidelines for the Health Risk Assessment of Chemical Mixtures represent the Agency's science policy and are a procedural guide for evaluating data on the health risks from exposures to chemical mixtures. The emphasis is on dose response and risk characterization.

The principles and concepts put forth in the Guidelines remain in effect. However, in 2000, EPA issued a new document, Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures (EPA/630/R-00/002 - August 2000). While the Guidelines describe broad principles and include few specific procedures, the 2000 guidance is a supplement that is intended to provide more detail on these principles and their applications.

• Guidelines for the Health Risk Assessment of Chemical Mixtures (PDF)(38 pp, 306 K, September 1986, 630-R-98-002)