File: README.TXT


                     Acute-to-Chronic Estimation (ACE) 
                   with Time-Concentration-Effect Models


                        Version 2.0, December, 2003
  

               Center for Exposure Assessment Modeling (CEAM)
       National Exposure Research Lab - Ecosystems Research Division
                  Office of Research and Development (ORD)
              U.S. Environmental Protection Agency (U.S. EPA)
                          960 College Station Road
                         Athens, Georgia 30605-2700

                                706/355-8400



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CONTENTS

  INTRODUCTION
  DOCUMENTATION
  INSTALLATION
  TECHNICAL HELP CONTACT

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INTRODUCTION

ICE and ACE were developed by the U.S. EPA in collaboration with other
federal agencies, industry, and universities to address data gaps in species
sensitivity and reduce reliance on uncertainty factors in ecological risk
assessment.

The Acute-to-Chronic Estimation (ACE) with Time-Concentration-Effect Models
software allows prediction of chronic toxicity from acute toxicity datasets.
ACE uses linear regression and accelerated life testing to predict no-effect
and low-effect concentrations for chronic mortality.

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DOCUMENTATION

Users should refer to the documents listed below to operate and apply the 
model system.  These documents should be retained by the requester for 
reference.

Document Name                                  File Name
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~     ~~~~~~~~~~~~~~~~~~
ACE installation and user support guide        README.TXT

ACE system abstract                            ABSTRACT.TXT

Acute-to-Chronic Estimation (ACE) with         Ace.pdf
Time-Concentration-Effect Models User 
Manual (EPA/600/R-03/107)

The user's manual (Ace.pdf) is included in the self-extracting Zip file 
program ACE_Manual.EXE.

Files with a file name extension of .PDF are in Adobe Acrobat format and
require Adobe Acrobat Reader software available at no charge from
http://www.adobe.com/.

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INSTALLATION

System Requirements:

  Microsoft Windows 95, 98, 2000, NT and XP (Windows 98 or later is suggested)
  Minimum 16 MB RAM (64 MB or greater is suggested)
  CPU speed of over 200 MHz is suggested (ACE will work with less, but is
    very slow)
  6 MB available hard disk space
  Mouse or pointing device
  Printer (optional).

Remove any existing versions of ACE before installing the new one or 
malfunctions may occur.

To remove old ACE software:

  1. Double click My Computer.
  2. Double click Control Panel.
  3. Double click Add/Remove Programs.
  4. Click ACE.
  5. Click Delete or Change/Remove.

To install new ACE software:

  1. Place the ACE CD in the CD ROM drive.
  2. Click Start button.
  3. Select Run from the menu.
  4. Select Browse from the Run window.
  5. Select drive letter associated with the CD drive from Browse window 
     (or ACE  2003 [D:]).
  6. Double-click Setup file or D:\SETUP.EXE file.
  7. Click OK.
  8. Windows now walks you through the installation process.  If a "Yes" or
     "No" question is encountered, choose "Yes".
  9. Following installation, the ACE program can be accessed by clicking 
     Start, Programs, and then ACE.  You can create an icon on the Desktop 
     screen by placing the mouse pointer on the ACE icon, holding down on the
     control button, and dragging the icon to desired location on the screen.

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TECHNICAL HELP CONTACT

For questions or information concerning the distribution or installation of
CEAM software, documentation, or data please contact CEAM at:

  Phone: 706-355-8400
  Fax: 706-355-8104
  E-mail: ceam@epamail.epa.gov
  Mail:
    Center for Exposure Assessment Modeling (CEAM)
    National Exposure Research Laboratory - Ecosystems Research Division
    U.S. Environmental Protection Agency (U.S. EPA)
    960 College Station Road
    Athens, Georgia 30605-2700

CEAM operates and maintains a listserver system named CEAM-USERS. The CEAM-
USERS listserver is an automated mailing list system which broadcasts up-to-
date information concerning CEAM software product updates and releases as
well as hints on software installation and use. Subscribers may broadcast
messages to other list subscribers to ask and answer questions about exposure
assessment modeling topics. Instructions for subscribing, posting messages,
and managing membership setting are available on the CEAM Web site at the
URL:

  http://www.epa.gov/ceampubl/listserv.htm


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