You may need a PDF reader to view some of the files on this page. See EPA’s About PDF page to learn more.Substitutes are reviewed on the basis of environmental and health risks, including factors such as ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptableacceptableThis designation means that a substitute may be used, without restriction, to replace the relevant ODS within the end-use specified. For example, HCFC-22 is an acceptable substitute for R-502 in industrial process refrigeration. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. and unacceptableUnacceptableThis designation means that it is illegal to use a product as a substitute for an ODS in a specific end-use. For example, HCFC-141b is an unacceptable substitute for CFC-11 in building chillers. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. substitutes are updated several times each year. The list of substitutes is shown below.

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Substitute	Trade Name(s)	ODPODPA number that refers to the amount of ozone depletion caused by a substance. The ODP is the ratio of the impact on ozone of a chemical compared to the impact of a similar mass of CFC-11. Thus, the ODP of CFC-11 is defined to be 1.0. Other CFCs and HCFCs have ODPs that range from 0.01 to 1.0. The halons have ODPs ranging up to 10. Carbon tetrachloride has an ODP of 1.2, and methyl chloroform's ODP is 0.11. HFCs have zero ODP because they do not contain chlorine. A table of all ozone-depleting substances (http://www.epa.gov/ozone/science/ods/index.html) shows their ODPs, GWPs, and CAS numbers.	GWPGWPThe index used to translate the level of emissions of various gases into a common measure in order to compare the relative radiative forcing of different gases without directly calculating the changes in atmospheric concentrations. GWPs are calculated as the ratio of the radiative forcing that would result from the emissions of one kilogram of a greenhouse gas to that from the emission of one kilogram of carbon dioxide over a period of time (usually 100 years). Gases involved in complex atmospheric chemical processes have not been assigned GWPs. See lifetime.	Flammable	SNAP Listing Date	Listing Status	Further Information
AB Technology		0	5 or less	yes	March 18, 1994	Acceptable
Acetone		0	0.5	yes	June 16, 2010	Acceptable
Carbon Dioxide		0	1	no	March 18, 1994; June 8, 1999	Acceptable
Methyl Formate	EcomateTM	0	5 or less	yes	September 28, 2006	Acceptable
Electroset Technology		0	N/A	N/A	August 26, 1994; June 16, 2010	Acceptable
Exxsol Blowing Agents	Exxsol Blowing Agents	0	5 or less	yes	December 6, 1999; June 16, 2010	Acceptable
HFC-134a		0	1,430	no	March 18, 1994; June 8, 1999; July 20, 2015; December 1, 2016	Unacceptable, except where allowed under narrowed use limits for military or space- and aeronautics-related applications, as of January 1, 2017. [1] Unacceptable for military applications as of January 1, 2022 and for space- and aeronautics-related applications as of January 1, 2025. [1]
HFC-152a		0	124	yes	March 18, 1994; June 8, 1999	Acceptable
HFC-245fa		0	1,030	no	December 6, 1999; July 20, 2015; December 1, 2016	Unacceptable, except where allowed under narrowed use limits for military or space- and aeronautics-related applications, as of January 1, 2017. [1] Unacceptable for military applications as of January 1, 2022 and for space- and aeronautics-related applications as of January 1, 2025. [1]
HFC-365mfc		0	794	yes	September 30, 2009; June 16, 2010; July 20, 2015; December 1, 2016	Unacceptable, except where allowed under narrowed use limits for military or space- and aeronautics-related applications, as of January 1, 2017. [1] Unacceptable for military applications as of January 1, 2022 and for space- and aeronautics-related applications as of January 1, 2025. [1]
HFO-1336mzz(E)	Opteon™ 1150	0	16	no	December 11, 2020	Acceptable
HFO–1336mzz(Z) ((Z)-1,1,1,4,4,4-hexafluorobut-2-ene)	Formacel® 1100, FEA-1100	0	9	no	October 21, 2014	Acceptable
Methylal (dimethoxymethane)		0	<3	yes	October 21, 2014	Acceptable
Methylene Chloride		0	8.7	no	December 1, 2016	Unacceptable as of January 3, 2017.
Saturated Light Hydrocarbons (C3-C6)		0	3 - 10	yes	August 26, 1994; April 11, 2000; June 16, 2010	Acceptable
Trans-1-chloro-3,3,3-trifluoroprop-1-ene	Solstice® 1233zd(E)	0.00024 - 0.00034	4.7 - 7	no	October 21, 2014	Acceptable
Water		0	N/A	no	June 8, 1999	Acceptable
HCFC-124		0.022	609	no	July 22, 2002	Unacceptable	Alternatives exist with lower or zero ODP.
HCFC-141b		0.12	725	no	September 30, 2004; July 20, 2015	Unacceptable	Alternatives exist with lower or zero ODP.
HCFC-22, HCFC-142b or blends thereof		>0	N/A	no	July 22, 2002; July 20, 2015	Unacceptable	Alternatives exist with lower or zero ODP.

¹ As per EPA’s April 27, 2018 guidance (83 FR 18431), based on the court’s partial vacatur, in the near term EPA will not apply these HFC listings in the 2015 Rule, pending a rulemaking.