You may need a PDF reader to view some of the files on this page. See EPA’s About PDF page to learn more.Substitutes are reviewed on the basis of environmental and health risks, including factors such as ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptableacceptableThis designation means that a substitute may be used, without restriction, to replace the relevant ODS within the end-use specified. For example, HCFC-22 is an acceptable substitute for R-502 in industrial process refrigeration. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. and unacceptableUnacceptableThis designation means that it is illegal to use a product as a substitute for an ODS in a specific end-use. For example, HCFC-141b is an unacceptable substitute for CFC-11 in building chillers. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. substitutes are updated several times each year. The list of substitutes is shown below.

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Substitute	Trade Name(s)	Retrofit/New	ODPODPA number that refers to the amount of ozone depletion caused by a substance. The ODP is the ratio of the impact on ozone of a chemical compared to the impact of a similar mass of CFC-11. Thus, the ODP of CFC-11 is defined to be 1.0. Other CFCs and HCFCs have ODPs that range from 0.01 to 1.0. The halons have ODPs ranging up to 10. Carbon tetrachloride has an ODP of 1.2, and methyl chloroform's ODP is 0.11. HFCs have zero ODP because they do not contain chlorine. A table of all ozone-depleting substances (https://www3.epa.gov/ozone/science/ods/index.html) shows their ODPs, GWPs, and CAS numbers.	GWPGWPThe index used to translate the level of emissions of various gases into a common measure in order to compare the relative radiative forcing of different gases without directly calculating the changes in atmospheric concentrations. GWPs are calculated as the ratio of the radiative forcing that would result from the emissions of one kilogram of a greenhouse gas to that from the emission of one kilogram of carbon dioxide over a period of time (usually 100 years). Gases involved in complex atmospheric chemical processes have not been assigned GWPs. See lifetime.	ASHRAEASHRAEASHRAE is an international organization that establishes standards for the uniform testing and rating of heating, ventilation, air conditioning, and refrigeration equipment. It also conducts related research, disseminates publications, and provides continuing education to its members. Designation (Safety Classification)	SNAP Listing Date	Listing Status	Further Information
Ammonia Absorption		N	0	0	B2	September 5, 1996	Acceptable
Ammonia Vapor Compression		N	0	0	B2	September 5, 1996	Acceptable
Desiccant Cooling		N	0	N/A	N/A	June 16, 2010	Acceptable
Evaporative Cooling		N	0	N/A	N/A	September 5, 1996	Acceptable
FOR12A	FOR12A	R/N	0	1,100	A1	December 18, 2000	Acceptable
FOR12B	FOR12B	R/N	0	1,000	A1	December 18, 2000	Acceptable
HCFC-124		R/N	0.022	609	A1	March 18, 1994	Acceptable
HCFC-22		N	0.055	1,810	A1	January 13, 1995	Acceptable	EPA recommends that HCFC–22 only be used where ambient temperatures are lower than 115°F because of very high system pressures.
HFC-134a		N	0	1,430	A1	January 13, 1995; June 16, 2010	Acceptable	Applicable to new uses below 125 degrees F ambient
HFC-245fa	Genetron® 245fa	R/N	0	1,030	A1	March 29, 2006	Acceptable
HFO-1336mzz(Z) ((Z)-1,1,1,4,4,4-hexafluorobut-2-ene)	Opteon® MZ	N	0	9	A1	May 23, 2016	Acceptable
R-414B	Hot Shot, Kar Kool, HCFC Blend Omicron	R/N	0.098	3,337	A1	December 20, 2002	Acceptable
Ikon A	Ikon-12, Blend Zeta	N	0	N/A	A1	June 19, 2000	Acceptable
Ikon B		R/N	0	N/A	A1	December 6, 1999	Acceptable
R-125/R-134a/R-600a (28.1/70.0/1.9)	NU-22 old composition	R/N	0	1,990	A1	June 16, 2010	Acceptable
R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5)	ICOR AT-22	R/N	0	2,530	A1	March 29, 2006	Acceptable
R-401A	SUVA MP-39	R	0.037	1,182	A1	January 13, 1995	Acceptable
R-401B	SUVA MP-66	R	0.040	1,288	A1	January 13, 1995	Acceptable
R-404A	SUVA HP-62	R/N	0	3,920	A1	December 20, 2002	Acceptable
R-407C	Suva 407C, Klea 407C	R/N	0	1,770	A1	December 20, 2002; August 21, 2003	Acceptable
R-407F	Genetron Performax LT	R/N	0	1,820	A1	October 4, 2011	Acceptable
R-410A	AZ-20, Suva 9100, Puron	N	0	2,090	A1	February 8, 1996; December 20, 2002	Acceptable
R-410B		N	0	2,230	A1	February 8, 1996	Acceptable
R-417A	ISCEON 59, NU-22	R/N	0	2,350	A1	December 6, 1999; December 20, 2002; June 16, 2010	Acceptable
R-420A	Choice R-420A	R/N	0.008	1,536	A1	October 1, 2004	Acceptable
R-421A	Choice R-421A	R/N	0	2,630	A1	September 28, 2006	Acceptable
R-421B	Choice R-421B	R/N	0	3,190	A1	N/A	Acceptable
R-422B	ICOR XAC1, NU-22B	R/N	0	2,530	A1	March 29, 2006	Acceptable
R-422C	ICOR XLT1	R/N	0	3,390	A1	March 29, 2006	Acceptable
R-422D	ISCEON MO29	R/N	0	2,730	A1	September 28, 2006	Acceptable
R-423A	ISCEON 39TC	R/N	0	2,280	A1	March 22, 2002; June 16, 2010	Acceptable
R-424A	RS-44	R/N	0	2,440	A1	September 28, 2006	Acceptable
R-426A	RS-24	R/N	0	1,510	A1	September 28, 2006; June 16, 2010	Acceptable
R-427A	Forane 427A	R	0	2,140	A1	January 2, 2009	Acceptable
R-434A	RS-45	R/N	0	3,250	A1	October 4, 2007	Acceptable
R-437A	KDD6, ISCEON MO49 Plus	R/N	0	1,810	A1	January 2, 2009	Acceptable
R-438A	KDD5, ISCEON MO99	R/N	0	2,270	A1	October 4, 2007; June 16, 2010	Acceptable
R-450A	Solstice® N-13	R/N	0	601	A1	October 21, 2014	Acceptable
R-507, R-507A	AZ-50	R/N	0	3,990	A1	September 5, 1996; December 20, 2002	Acceptable
R-513A	Opteon® XP 10	R/N	0	630	A1	July 16, 2015	Acceptable
R-515B		N	0	287	A1	December 11, 2020	Acceptable
R-744 (Carbon Dioxide, CO2)		N	0	1	A1	May 23, 2016	Acceptable
RS-24 (2002 formulation)		R/N	0	1,510	A1	December 20, 2002; June 16, 2010	Acceptable
RS-44 (2003 formulation)		R/N	0	2,420	A1	June 16, 2010	Acceptable
THR-02		R/N	0	N/A	A1	December 6, 1999	Acceptable
THR-03		R/N	0	N/A	A1	December 6, 1999	Acceptable

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