Substitutes in Industrial Process Air Conditioning
You may need a PDF reader to view some of the files on this page. See EPA’s About PDF page to learn more.Substitutes are reviewed on the basis of environmental and health risks, including factors such as ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptableacceptableThis designation means that a substitute may be used, without restriction, to replace the relevant ODS within the end-use specified. For example, HCFC-22 is an acceptable substitute for R-502 in industrial process refrigeration. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. and unacceptable
UnacceptableThis designation means that it is illegal to use a product as a substitute for an ODS in a specific end-use. For example, HCFC-141b is an unacceptable substitute for CFC-11 in building chillers. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. substitutes are updated several times each year. The list of substitutes is shown below.
Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.
Substitute | Trade Name(s) | Retrofit/New | ODP![]() |
GWP![]() |
ASHRAE![]() Designation (Safety Classification) |
SNAP Listing Date | Listing Status | Further Information |
---|---|---|---|---|---|---|---|---|
Ammonia Absorption | N | 0 | 0 | B2 | September 5, 1996 | Acceptable | ||
Ammonia Vapor Compression | N | 0 | 0 | B2 | September 5, 1996 | Acceptable | ||
Desiccant Cooling | N | 0 | N/A | N/A | June 16, 2010 | Acceptable | ||
Evaporative Cooling | N | 0 | N/A | N/A | September 5, 1996 | Acceptable | ||
FOR12A | FOR12A | R/N | 0 | 1,100 | A1 | December 18, 2000 | Acceptable | |
FOR12B | FOR12B | R/N | 0 | 1,000 | A1 | December 18, 2000 | Acceptable | |
HCFC-124 | R/N | 0.022 | 609 | A1 | March 18, 1994 | Acceptable | ||
HCFC-22 | N | 0.055 | 1,810 | A1 | January 13, 1995 | Acceptable | EPA recommends that HCFC–22 only be used where ambient temperatures are lower than 115°F because of very high system pressures. | |
HFC-134a | N | 0 | 1,430 | A1 | January 13, 1995; June 16, 2010 |
Acceptable | Applicable to new uses below 125 degrees F ambient | |
HFC-245fa | Genetron® 245fa | R/N | 0 | 1,030 | A1 | March 29, 2006 | Acceptable | |
HFO-1336mzz(Z) ((Z)-1,1,1,4,4,4-hexafluorobut-2-ene) | Opteon® MZ | N | 0 | 9 | A1 | May 23, 2016 | Acceptable | |
R-414B | Hot Shot, Kar Kool, HCFC Blend Omicron | R/N | 0.098 | 3,337 | A1 | December 20, 2002 | Acceptable | |
Ikon A | Ikon-12, Blend Zeta | N | 0 | N/A | A1 | June 19, 2000 | Acceptable | |
Ikon B | R/N | 0 | N/A | A1 | December 6, 1999 | Acceptable | ||
R-125/R-134a/R-600a (28.1/70.0/1.9) | NU-22 old composition | R/N | 0 | 1,990 | A1 | June 16, 2010 | Acceptable | |
R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5) | ICOR AT-22 | R/N | 0 | 2,530 | A1 | March 29, 2006 | Acceptable | |
R-401A | SUVA MP-39 | R | 0.037 | 1,182 | A1 | January 13, 1995 | Acceptable | |
R-401B | SUVA MP-66 | R | 0.040 | 1,288 | A1 | January 13, 1995 | Acceptable | |
R-404A | SUVA HP-62 | R/N | 0 | 3,920 | A1 | December 20, 2002 | Acceptable | |
R-407C | Suva 407C, Klea 407C | R/N | 0 | 1,770 | A1 | December 20, 2002; August 21, 2003 |
Acceptable | |
R-407F | Genetron Performax LT | R/N | 0 | 1,820 | A1 | October 4, 2011 | Acceptable | |
R-410A | AZ-20, Suva 9100, Puron | N | 0 | 2,090 | A1 | February 8, 1996; December 20, 2002 |
Acceptable | |
R-410B | N | 0 | 2,230 | A1 | February 8, 1996 | Acceptable | ||
R-417A | ISCEON 59, NU-22 | R/N | 0 | 2,350 | A1 | December 6, 1999; December 20, 2002; June 16, 2010 |
Acceptable | |
R-420A | Choice R-420A | R/N | 0.008 | 1,536 | A1 | October 1, 2004 | Acceptable | |
R-421A | Choice R-421A | R/N | 0 | 2,630 | A1 | September 28, 2006 | Acceptable | |
R-421B | Choice R-421B | R/N | 0 | 3,190 | A1 | N/A | Acceptable | |
R-422B | ICOR XAC1, NU-22B | R/N | 0 | 2,530 | A1 | March 29, 2006 | Acceptable | |
R-422C | ICOR XLT1 | R/N | 0 | 3,390 | A1 | March 29, 2006 | Acceptable | |
R-422D | ISCEON MO29 | R/N | 0 | 2,730 | A1 | September 28, 2006 | Acceptable | |
R-423A | ISCEON 39TC | R/N | 0 | 2,280 | A1 | March 22, 2002; June 16, 2010 |
Acceptable | |
R-424A | RS-44 | R/N | 0 | 2,440 | A1 | September 28, 2006 | Acceptable | |
R-426A | RS-24 | R/N | 0 | 1,510 | A1 | September 28, 2006; June 16, 2010 |
Acceptable | |
R-427A | Forane 427A | R | 0 | 2,140 | A1 | January 2, 2009 | Acceptable | |
R-434A | RS-45 | R/N | 0 | 3,250 | A1 | October 4, 2007 | Acceptable | |
R-437A | KDD6, ISCEON MO49 Plus | R/N | 0 | 1,810 | A1 | January 2, 2009 | Acceptable | |
R-438A | KDD5, ISCEON MO99 | R/N | 0 | 2,270 | A1 | October 4, 2007; June 16, 2010 |
Acceptable | |
R-450A | Solstice® N-13 | R/N | 0 | 601 | A1 | October 21, 2014 | Acceptable | |
R-507, R-507A | AZ-50 | R/N | 0 | 3,990 | A1 | September 5, 1996; December 20, 2002 |
Acceptable | |
R-513A | Opteon® XP 10 | R/N | 0 | 630 | A1 | July 16, 2015 | Acceptable | |
R-515B | N | 0 | 287 | A1 | December 11, 2020 | Acceptable | ||
R-744 (Carbon Dioxide, CO2) | N | 0 | 1 | A1 | May 23, 2016 | Acceptable | ||
RS-24 (2002 formulation) | R/N | 0 | 1,510 | A1 | December 20, 2002; June 16, 2010 |
Acceptable | ||
RS-44 (2003 formulation) | R/N | 0 | 2,420 | A1 | June 16, 2010 | Acceptable | ||
THR-02 | R/N | 0 | N/A | A1 | December 6, 1999 | Acceptable | ||
THR-03 | R/N | 0 | N/A | A1 | December 6, 1999 | Acceptable |
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