You may need a PDF reader to view some of the files on this page. See EPA’s About PDF page to learn more.Substitutes are reviewed on the basis of environmental and health risks, including factors such as ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptableacceptableThis designation means that a substitute may be used, without restriction, to replace the relevant ODS within the end-use specified. For example, HCFC-22 is an acceptable substitute for R-502 in industrial process refrigeration. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. and unacceptableUnacceptableThis designation means that it is illegal to use a product as a substitute for an ODS in a specific end-use. For example, HCFC-141b is an unacceptable substitute for CFC-11 in building chillers. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. substitutes are updated several times each year. The list of substitutes is shown below.

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Substitute	Trade Name(s)	Retrofit/New	ODPODPA number that refers to the amount of ozone depletion caused by a substance. The ODP is the ratio of the impact on ozone of a chemical compared to the impact of a similar mass of CFC-11. Thus, the ODP of CFC-11 is defined to be 1.0. Other CFCs and HCFCs have ODPs that range from 0.01 to 1.0. The halons have ODPs ranging up to 10. Carbon tetrachloride has an ODP of 1.2, and methyl chloroform's ODP is 0.11. HFCs have zero ODP because they do not contain chlorine. A table of all ozone-depleting substances (https://www3.epa.gov/ozone/science/ods/index.html) shows their ODPs, GWPs, and CAS numbers.	GWPGWPThe index used to translate the level of emissions of various gases into a common measure in order to compare the relative radiative forcing of different gases without directly calculating the changes in atmospheric concentrations. GWPs are calculated as the ratio of the radiative forcing that would result from the emissions of one kilogram of a greenhouse gas to that from the emission of one kilogram of carbon dioxide over a period of time (usually 100 years). Gases involved in complex atmospheric chemical processes have not been assigned GWPs. See lifetime.	ASHRAE Designation (Safety Classification)	SNAP Listing Date	Listing Status
Ammonia Vapor Compression with Secondary Loop		N	0	0	B2	March 18, 1994; September 5, 1996	Acceptable
FOR12A	FOR12A	R/N	0	1,100	A1	December 18, 2000	Acceptable
FOR12B	FOR12B	R/N	0	1,000	A1	December 18, 2000	Acceptable
RB-276	Free Zone, HCFC Blend Delta	R/N	0.013	1,592	A1	September 5, 1996	Acceptable
Freeze 12	Freeze 12	R/N	0.013	1,606	A1	September 5, 1996	Acceptable
R-416A	FRIGC FR-12, HCFC Blend Beta	R/N	0.009	1,081	A1	February 8, 1996; February 24, 1998	Acceptable
G2018C	G2018C	R/N	0.053	1,731	A1	September 5, 1996	Acceptable
GHG-HP	HCFC Blend Lambda	R/N	0.056	1,893	A1	February 8, 1996	Acceptable
R-414A	GHG-X4, Autofrost, Chill-it, HCFC Blend Xi	R/N	0.045	1,478	A1	September 5, 1996	Acceptable
GHG-X5	GHG-X5	R/N	0.032	2,377	A1	June 3, 1997	Acceptable
HCFC-22		R/N	0.055	1,810	A1	March 18, 1994	Acceptable
HCFC-22/HCFC-142b		R/N	0.055-0.065	1,810-2,310	A1	June 3, 1997	Acceptable
HFC-134a		R/N	0	1,430	A1	March 18, 1994	Acceptable
HFC-134a/HBr (92/8)		N	0.0016	N/A	A1	May 23, 2001	Acceptable: Only acceptable for use as the primary heat transfer fluid in secondary-loop equipment for not-in-kind replacements.
HFC-227ea		N	0	3,220	A1	March 18, 1994; July 20, 2015	Unacceptable in new equipment as of January 1, 2017. [1]
HFE-449s1 (methoxynonafluorobutane, iso and normal)	Novec™ 7100 Engineered Fluid (HFE-7100)	N	0	297	A1	December 18, 2000; June 16, 2010	Acceptable: Only acceptable for use as a secondary heat transfer fluid in not-in-kind systems.
HFE-569sf2 (ethoxynonafluorobutane, iso and normal)	Novec™ 7200 Engineered Fluid (HFE-7200)	N	0	59	N/A	December 18, 2000; June 16, 2010	Acceptable: Only acceptable for use as a secondary heat transfer fluid in not-in-kind systems.
R-414B	Hot Shot, Kar Kool, HCFC Blend Omicron	R/N	0.098	3,337	A1	September 5, 1996	Acceptable
R-417C	Hot Shot 2	R	0	1,820	A1	October 4, 2011	Acceptable
Ikon A	Ikon-12, Blend Zeta	R/N	0	N/A	A1	June 19, 2000	Acceptable
Ikon B		R/N	0	N/A	A1	December 6, 1999	Acceptable
R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5)	ICOR AT-22	R/N	0	2,530	A1	June 16, 2010	Acceptable
R-401A	SUVA MP-39	N	0.037	1,182	A1	January 13, 1995	Acceptable
R-401B	SUVA MP-66	N	0.040	1,288	A1	January 13, 1995	Acceptable
R-402A	HP-80	R/N	0.019	2,746	A1	March 18, 1994	Acceptable
R-402B	HP-81	R/N	0.03	2,379	A1	March 18, 1994	Acceptable
R-404A	SUVA HP-62	R/N	0	3,920	A1	March 18, 1994; December 20, 2002; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. [1] Unacceptable in new equipment as of January 1, 2018. [1]
R-406A	GHG-12, GHG-X3, McCool, Autofrost X3	R	0.057	1,900	A2	August 26, 1994	Acceptable
R-407A	Klea 60, Klea 407A	R/N	0	2,110	A1	August 26, 1994; January 2, 2009	Acceptable
R-407B	Klea 61	R/N	0	2,800	A1	August 26, 1994; June 16, 2010; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. [1] Unacceptable in new equipment as of January 1, 2018. [1]
R-407C	Suva 407C, Klea 407C	R/N	0	1,770	A1	February 8, 1996; December 20, 2002; August 21, 2003	Acceptable
R-407F	Genetron Performax LT	R/N	0	1,820	A1	October 4, 2011	Acceptable
R-407H		R/N	0	1,500	A1	July 21, 2017	Acceptable
R-408A	HCFC Blend Epsilon	R	0.026	55	A1	August 26, 1994	Acceptable
R-409A	HCFC Blend Gamma	R	0.047	1,558	A1	August 26, 1994	Acceptable
R-410A	AZ-20, Suva 9100, Puron	N	0	2,090	A1	February 8, 1996; December 20, 2002	Acceptable
R-410B		N	0	2,230	A1	February 8, 1996; June 16, 2010	Acceptable
R-411A		R/N	0.048	1,600	A2	February 8, 1996	Acceptable
R-411B		R/N	0.052	1,700	A2	February 8, 1996	Acceptable
R-417A	ISCEON 59, NU-22	R/N	0	2,350	A1	December 6, 1999; December 20, 2002; June 16, 2010	Acceptable
R-420A	Choice R-420A	R/N	0.008	1,536	A1	October 1, 2004	Acceptable
R-421A	Choice R-421A	R/N	0	2,630	A1	September 28, 2006; June 16, 2010	Acceptable
R-421B	Choice R-421B	R/N	0	3,190	A1	September 28, 2006; June 16, 2010; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. [1] Unacceptable in new equipment as of January 1, 2018. [1]
R-422A	ISCEON 79	R/N	0	3,140	A1	October 1, 2004; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. [1] Unacceptable in new equipment as of January 1, 2018. [1]
R-422B	ICOR XAC1, NU-22B	R/N	0	2,530	A1	March 29, 2006	Acceptable
R-422C	ICOR XLT1	R/N	0	3,390	A1	March 29, 2006; June 16, 2010; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. [1] Unacceptable in new equipment as of January 1, 2018. [1]
R-422D	ISCEON MO29	R/N	0	2,730	A1	September 28, 2006; June 16, 2010; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. [1] Unacceptable in new equipment as of January 1, 2018. [1]
R-424A	RS-44	R/N	0	2,440	A1	September 28, 2006; June 16, 2010	Acceptable
R-426A	RS-24	R/N	0	1,510	A1	September 28, 2006; June 16, 2010	Acceptable
R-427A	Forane 427A	R	0	2,140	A1	January 2, 2009; June 16, 2010	Acceptable
R-428A	RS-52	R/N	0	3,610	A1	October 4, 2007; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. [1] Unacceptable in new equipment as of January 1, 2018. [1]
R-434A	RS-45	R/N	0	3,250	A1	October 4, 2007; June 16, 2010; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. [1] Unacceptable in new equipment as of January 1, 2018. [1]
R-437A	KDD6, ISCEON MO49 Plus	R/N	0	1,810	A1	January 2, 2009	Acceptable
R-438A	KDD5, ISCEON MO99	R/N	0	2,270	A1	October 4, 2007; June 16, 2010	Acceptable
R-442A	RS-50	R/N	0	1,890	A1	July 21, 2017	Acceptable
R-452A	Opteon XP44	R/N	0	2,140	A1	July 21, 2017	Acceptable
R-452C	Forane® 452C	R/N	0	2,200	A1	July 21, 2017	Acceptable
R-453A	RS-70	R/N	0	1,770	A1	July 21, 2017	Acceptable
R-458A	Bluon TdX 20	R/N	0	1,650	A1	July 21, 2017	Acceptable
R-507, R-507A	AZ-50	R/N	0	3,990	A1	March 18, 1994; December 20, 2002; September 30, 2009; July 20, 2015	Unacceptable in retrofit equipment as of July 20, 2016. [1] Unacceptable in new equipment as of January 1, 2018. [1]
R-513A	Opteon® XP 10	R/N	0	630	A1	July 16, 2015	Acceptable
R-744 (Carbon Dioxide, CO2)		N	0	1	A1	September 30, 2009	Acceptable
RS-24 (2002 formulation)		R/N	0	1,510	A1	December 20, 2002; June 16, 2010	Acceptable
RS-44 (2003 formulation)		R/N	0	2,420	A1	June 16, 2010	Acceptable
Self-chilling cans using CO2		N	0	1	A1	February 24, 1998	Acceptable
SP34E	SP34E	R/N	0	<1,470	A1	December 18, 2000; June 16, 2010	Acceptable
THR-02		R/N	0	N/A	A1	December 6, 1999	Acceptable
THR-03		R/N	0	N/A	A1	December 6, 1999	Acceptable
THR-04		R/N	>0	N/A	A1	June 8, 1999	Acceptable
R-450A	Solstice N-13	R/N	0	601	A1	October 21, 2014	Acceptable
R-448A	Solstice® N-40	R/N	0	1,387	A1	July 16, 2015	Acceptable
R-449A	Opteon® XP 40	R/N	0	1,400	A1	July 16, 2015	Acceptable
R-449B	Forane® 449B	R/N	0	1,412	A1	October 11, 2016	Acceptable
R-513A	Opteon® XP 10	R/N	0	630	A1	July 16, 2015	Acceptable

¹ As per EPA’s April 27, 2018 guidance (83 FR 18431), based on the court’s partial vacatur, in the near term EPA will not apply these HFC listings in the 2015 Rule, pending a rulemaking.

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