The Integrated Risk Information System (IRIS) is a data base that contains EPA scientific consensus positions on potential human health effects from environmental contaminants. Since April 1996, EPA has solicited scientific information from the public for consideration in assessing the chronic health effects of eleven chemical substances. (See FR Vol. 61 No. 64 p. 14570.) Until 2015, the Agency would solicit comments on proposed assessments from what was called the IRIS Agenda to announce the new set of chemical health assessments for IRIS. The purpose of these notices was to communicate to the public the Agency's plans, and solicit scientific data and evaluations for consideration in EPA's new assessments. Eventually this was superseded by the IRIS Program Outlook tables.

Below is a list of past IRIS agendas are provided in the following table: