4 December 2013

EPA announced the dates have been set for the February 2014 IRIS Bimonthly Meeting. The preliminary material for diethyl phthalate (DEP) have also been released. Registration is not yet open.

7 November 2013

The National Research Council has released an Interim Report, called Critical Aspects of EPA’s IRIS Assessment of Inorganic Arsenic, that describes their recommendations to the IRIS Program for developing an updated assessment of inorganic arsenic. The report contains findings and recommendations related to six critical areas, including: 1) hazard identification; 2) systematic review; 3) assessment of causality; 4) mode of action; 5) susceptibility; and 6) dose-response analysis. (See the report in brief (2 pp, 250 K, About PDF)) [NRC Press Release Nov 7, 2013]

31 October 2013

EPA posted the presentations from the systematic review workshop that was held in August 2013.

30 October 2013

EPA announces a call for topics, speaker, and panelists for an upcoming Formaldehyde Workshop. EPA is planning a public workshop to discuss several scientific issues related to its draft Integrated Risk Information System (IRIS) assessment of formaldehyde (inhalation exposure). EPA is seeking suggestions from the public on topics and speakers/panelists related to three themes: (1) Epidemiological research examining the potential association between formaldehyde exposure and lymphohematopoietic cancers (leukemia and lymphomas); (2) Mechanistic evidence relevant to formaldehyde inhalation exposure and these types of cancers; and (3) Evidence pertaining to the influence of formaldehyde that is produced endogenously (by the body during normal biological processes) on the toxicity of inhaled formaldehyde, and implications for the health assessment. The deadline for submissions is November 22nd.

23 October 2013

Due to the Government shutdown, both the IRIS bimonthly Public Meeting and the Mouse Lung Tumor Workshops have been rescheduled into December and January respectfully. The next IRIS Bimonthly Public meeting will be held December 12-13, 2013 and is accepting re- registration at this time. If you would like to submit a presentation, the deadline is November 12, 2013. The Mouse Lung Tumor Workshop is rescheduled to January 7-8, 2014. Re-registration is also open for this event. Updates to the agenda's for both events will be posted shortly.

30 September 2013

EPA announced the release of the final IRIS Summary for Methanol and a new accompanying Toxicological Review (Noncancer) that have been added to the IRIS website. The Interagency Science Discussion Draft of the Methanol (Noncancer) IRIS assessment was also released.

30 September 2013

EPA announces an extension of the public comment period for the draft document, Toxicological Review of Benzo[a]pyrene (Public Comment Draft), originally announced in an August 21, 2013 Federal Register Notice. The deadline for submitting comments is November 21, 2013. [Federal Register Notice: Oct 24, 2013]

20 September 2013

EPA announced the release of the final IRIS Summary for 1,4-Dioxane and a new accompanying Toxicological Review (PDF) (419 pp) that have been added to the IRIS website. The Interagency Science Discussion Draft of the 1,4-Dioxane IRIS assessment (with Inhalation Update) was also released.

28 August 2013

EPA's Science Advisory Board (SAB) announces a request for nominations of experts to augment the SAB Chemical Assessment Advisory Committee (CAAC) for the review of the draft IRIS Toxicological Reviews of Ammonia and Trimethylbenzenes (Revised External Review Drafts), and the draft Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Revised External Review Draft). [Federal Register Notice: Aug 28,2013]

28 August 2013

EPA announces an extension of the public comment period for the draft document, Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Revised External Review Draft), originally announced in a July 23, 2013 Federal Register Notice. The deadline for submitting comments is October 11, 2013. [Federal Register Notice: Aug 28, 2013]

27 August 2013

EPA announced the release of the final IRIS Summary for Biphenyl and a new accompanying Toxicological Review (PDF) (225 pp) that have been added to the IRIS website. The Interagency Science Discussion Draft of the Biphenyl IRIS assessment was also released.

23 August 2013

EPA announces the availability of preliminary materials (literature search and search strategy, evidence tables, and exposure-response figures) for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). A public meeting to obtain input from stakeholders and the public on these preliminary materials is scheduled for October 23-24, 2013. [Federal Register Notice: Aug 9, 2013]

21 August 2013

EPA is announcing the release of the IRIS Toxicological Review of Benzo[a]pyrene (Public Comment Draft) with supplemental information for a 60 day public review and comment period. The interagency science consultation draft document and related comments are also available. The deadline for comments is October 21, 2013. This will also be added to the October 23-24, 2013 IRIS Bimonthly Meeting agenda. [Federal Register Notice: Aug 21, 2013]

12 August 2013

EPA announces a series of public meetings for the remainder of 2013 and throughout 2014 to increase stakeholder engangement on the development of IRIS Assessments. The first meeting is scheduled for October 23-24th and will highlight the following chemicals: tert-butyl alcohol (tert-butanol), ethyl-tert-butyl ether (ETBE), and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). Preliminary meeting materials including chemical literature (previously listed on the IRIS Literature Search page) and HERO links are now available. [Federal Register Notice: Aug 9, 2013]

6 August 2013

EPA announced release of the summary report for the November 2012 IRIS Public Stakeholder Meeting.

31 July 2013

EPA is announcing enhancements to the IRIS Program and assessment development process; new timelines for assessment development (PDF) (1 pp); and new stopping rules (PDF) (2 pp). For more details on these improvements, please see the fact sheet about the IRIS enhancements (PDF) (2 pp). Related story: EPA Science Blog: Writing down IRIS | [Press Release: July 31, 2013]

23 July 2013

EPA announced a revised draft document, entitled the "Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide", for public viewing and comments. The interagency science discussion draft document and related comments are also available. The deadline for comments is September 5, 2013. [Federal Register Notice: July 23, 2013]

23 July 2013

EPA announced the dates have been set for the September 2013 hexavalent chromium workshop. The deadline for registration is September 5, 2013.

22 July 2013

EPA opened registration for the systematic review workshop. The deadline for registration is August 21, 2013.

17 July 2013

EPA opened registration for the mouse lung tumors workshop. The deadline for registration is October 10, 2013.

2 July 2013

EPA announced the agenda is now available for the August 2013 systematic review workshop.

25 June 2013

EPA announced the peer review meeting for the review of the methanol noncancer IRIS assessment. Additional details and history for the methanol draft document are also available.

18 June 2013

October 24-25, 2013 Workshop on Chemically-induced Mouse Lung Tumors: Application to Human Health Assessment EPA announced a two-day, state-of-the-science workshop will cover a broad range of evidence from human, animal, and in vitro studies with a focus on specific chemicals (ethylbenzene, naphthalene, and styrene) causing lung tumors in mice and implicated in a proposed species- specific mode of action (MOA) based on metabolic and physiological susceptibility. The workshop is being sponsored and organized by EPA with input from (1) a volunteer committee of outside experts (including representatives from academic institutions, State agencies, other Federal organizations, NGOs, and industry), and (2) an internal working group of experts from EPA and other Federal partners. The workshop will include four separate sessions that will examine individual topic areas in detail, beginning with and continually referring back to the human relevance of data from animal and in vitro studies. More details will be provided as they become available.

3 May 2013

EPA announced a revised External Draft Toxicological Review for Methanol (noncancer) for public viewing and comments. Comments must be received on or before June 17, 2013. [Federal Register Notice: May 03, 2013]

1 May 2013

EPA announced that several scientific workshops will be held this summer/fall. Stay tuned for more announcements!

1 May 2013

EPA is seeking public input on specific topics related to systematic review of scientific studies and suggested speakers on this topic. This is part of EPA's plan to develop and implement approaches to improve the fundamental science of its assessments and to increase transparency and clarity in evaluating evidence and drawing conclusions. EPA will use this input to inform the development of one or more public workshops that will take place in the summer or fall of 2013 and will focus on issues related to the use of a systematic review process for evaluating potential health hazards of chemical exposures.

4 April 2013

The National Research Council (NRC) hosts a Second Inorganic Arsenic Meeting

2 April 2013

EPA's SAB Chemical Assessment Advisory Committee meets to discuss next steps to advise the IRIS program on upcoming toxicological reviews.

5 February 2013

IRISTrack Schedule Updates
EPA's IRIS Program is announcing updated schedules for several chemicals in the assessment development process. The chemical assessments with new schedules represent a subset of the entire IRIS agenda. These schedules incorporate additional stakeholder engagement early in the assessment development process. For several assessments that have already undergone public comment and external peer review, the schedules reflect EPA's decision to obtain further public comment and external peer review of the revisions due to the nature of the peer review comments. Finally, some schedules reflect assessments that will undergo external peer review by EPA's newly formed Science Advisory Board Chemical Assessment Advisory Committee. Additional schedules will be released in the near future. The release of these schedules represents the IRIS Program's continuing efforts to improve the assessment development process, meet the needs of the American public, and meet our goal to complete the IRIS assessments in a timely manner.

30 January 2013

EPA Materials submitted to the National Research Council committee reviewing the IRIS assessment development process.

30 January 2013

Final Review Report Available on the Toxicological Review of Libby Amphibole Asbestos
EPA's Science Advisory Board has released the final report on the "Review of EPA's Draft Assessment Entitled Toxicological Review of Libby Amphibole Asbestos (August 2011)."

25 January 2013

EPA's Science Advisory Board announces the establishment of the Chemical Assessment Advisory Committee (CAAC) for review of IRIS Assessments. The charter of the new CAAC committee is to provide advice regarding Toxicological Reviews of environmental chemicals available on EPA’s Integrated Risk Information System (IRIS). EPA will also consult with the committee on questions regarding the Integrated Risk Information System (IRIS) Program. This action continues the agency’s efforts to further strengthen the IRIS program. See the original November 18, 2011 press release announcement.

18 January 2013

National Research Council (NRC) hosted a public workshop on planning and scoping for the inorganic arsenic assessment on January 24-25, 2013. The NRC held a public workshop in Washington DC, on guidance for and review of EPA's IRIS Toxicological Review of Inorganic Arsenic.

8 January 2013

EPA hosted a Public Stakeholders Workshop for the IRIS assessment of Inorganic Arsenic on January 8-9, 2013, in Research Triangle Park, NC. Participants were asked to highlight significant new and emerging research, discuss methods for evaluating literature, identify critical research issues that may impact the toxicological review, and discuss approaches for dose- response. [Federal Register Notice Dec 6, 2012]

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20 December 2012

IRISTrack Schedule Notice
The IRIS Program is developing updated schedules for many chemicals in the assessment development process. These schedules will be regularly updated and will incorporate additional stakeholder engagement. New schedules will be announced on the IRIS website and available in IRISTrack in the near future. While the new schedules are being developed, the IRIS Program is continuing to improve the development process to meet our goal to complete IRIS assessments in a timely manner.

6 December 2012

EPA is announcing a Public Stakeholders Workshop for the IRIS assessment of Inorganic Arsenic on January 8-9, 2013, in Research Triangle Park, NC. Participants will be asked to highlight significant new and emerging research, discuss methods for evaluating literature, identify critical research issues that may impact the toxicological review, and discuss approaches for dose-response. The deadline for registration is January 2, 2013. [Federal Register Notice Dec 6, 2012]

14 November 2012

EPA announced a Public Stakeholders Workshop for the IRIS assessment of Inorganic Arsenic on November 29-30, 2012, in Research Triangle Park, NC. Participants will be asked to highlight significant new and emerging research, discuss methods for evaluating literature, identify critical research issues that may impact the toxicological review, and discuss approaches for dose- response. [Update: On 11/20, EPA announced that the public workshop to discuss the IRIS assessment for inorganic arsenic is being rescheduled for early next year. More information will be forthcoming.]

7 November 2012

EPA announces an IRIS Program public stakeholder meeting on November 13, 2012. The goal of the meeting is to hear the views of the IRIS Program’s many stakeholders about IRIS and changes that are underway to improve the Program.

8 August 2012

[Update] New Schedule for IRIS Inorganic Arsenic Assessment Announced
EPA has developed a new schedule for completing the IRIS Inorganic Arsenic assessment, which will be found in IRIS Track in the near future. EPA has decided to make further revisions to the inorganic arsenic assessment to more fully address scientific issues in the assessment. The revised draft will be released for public comment and rigorous, independent expert peer review. EPA will seek to have the peer review performed by the new Chemical Assessment Advisory Committee that is being formed under the auspices of the Science Advisory Board.

17 July 2012

IRIS announces Literature Search for Benzo[a]pyrene for public comment
IRIS announces the availability of the literature search for benzo[a]pyrene (CAS No. 50-32-8) (PDF) (80 pp) and is asking the public for any additional scientific information on health effects that may result from exposure to this chemical substance. [Federal Register Notice Jul 16, 2012]

28 June 2012

IRIS posts Literature Search for Acrylonitrile for public comment
IRIS posted the literature search for acrylonitrile (CAS No. 107-13-1) (PDF) (69 pp) and is asking the public for any additional scientific information on health effects that may result from exposure to this chemical substance.

26 June 2012

IRIS Toxicological Review of Trimethylbenzenes (External Review Draft Availabily & Listening Session)
EPA is announced the release of the draft IRIS Toxicological Review of Trimethylbenzenes (External Review Draft) for a 60-day public review and comment period. An upcoming Federal Register Notice will announced a public listening session to be held on August 1, 2012, and the close of the comment period as August 28, 2012. [Federal Register Notice Jun 29, 2012]

21 June 2012

IRIS posts Literature Search for Benzo[a]pyrene for public comment
IRIS posted the literature search for benzo[a]pyrene (CAS No. 50-32-8) (PDF) (80 pp) and is asking the public for any additional scientific information on health effects that may result from exposure to this chemical substance.

19 June 2012

Availability of Benchmark Dose Technical Guidance
EPA announced the availability of final Benchmark Dose Technical Guidance (BMD). This document was developed as part of an agency-wide guidance development program by a technical panel of the EPA's Risk Assessment Forum. [Federal Register Notice, June 19, 2012].

5 June 2012

IRIS Progress Report to Congress and companion path forward fact sheet for IRIS
EPA announced the release of the IRIS Progress Report to Congress. This report, delivered to Congress on April 20, 2012, provided Congress, stakeholders, and the public with an update on the IRIS Program and EPA’s progress toward implementing the recommendations from the National Research Council (NRC), received in April 2011, for improving the development of IRIS assessments.

1 June 2012

IRIS Toxicological Review of Ammonia (External Review Draft Availability & Listening Session Announcement)
EPA announced the release of the IRIS Toxicological Review of Ammonia (External Review Draft) for public review and comment. The 60-day public review and comment period. This notice also announced a public listening session that was held on July 12, 2012.
[Federal Register Notice, June 8, 2012] [Press Release, June 1, 2012]

24 May 2012

Availabilty of final reports from the peer review meetings of vanadium pentoxide and 1,4- dioxane (inhalation)
On March 7 and then on March 19, 2012, separate external peer review panel meetings were hosted by an independent contractor for the review of Toxicological Review of Vanadium Pentoxide: In Support of the Summary Information in the Integrated Risk Information System (IRIS) and the Toxicological Review of 1,4-Dioxane (Inhalation): In Support of the Summary Information in the Integrated Risk Information System (IRIS) respectfully. Completing these reviews, a final report of the comments from each of these workshop were collected and are now available.

16 May 2012

NAS Review of the IRIS Process
EPA announced that the National Academy of Sciences (NAS) will conduct a comprehensive review of the agency’s IRIS program’s assessment development process. This is a follow-up to when in April 2011, NAS recommended several ways to improve the development of IRIS assessments. EPA has embraced these recommendations and is implementing them using a phased approach. Future draft IRIS assessments released for public comment and peer review will demonstrate the progress EPA has made in implementing the NAS recommendations. [NAS IRIS Review Project page] [Press Release May 16, 2012]

14 May 2012

[Update] New Schedule for IRIS Acrylonitrile Assessment Announced
EPA has announced a new schedule for completing the IRIS Acrylonitrile assessment, which can be found in IRIS Track (IRISTrack - Acrylonitrile). EPA has decided to make further revisions to the acrylonitrile assessment to more fully address scientific issues in the assessment. The revised draft acrylonitrile assessment will be released for public comment and rigorous, independent expert peer review. EPA will seek to have the peer review performed by the new Chemical Assessment Advisory Committee that is being formed under the auspices of the Science Advisory Board.

7 May 2012

Announcement of 2012 IRIS Agenda for public comments
IRIS announced the IRIS 2012 agenda and is requesting scientific information on health effects that may result from exposure to the chemical substances on this agenda, including assessments that EPA is starting this year. [Federal Register Notice May 7, 2012]

16 April 2012

IRIS Archives External Review Drafts
The following draft assessments have been archived: acrylonitrile, arsenic, beryllium, dibutyl phthalate, dichlorobenzenes, ethyl tertiary butyl ether, chromium, mirex, and naphthalene. For several of these chemicals a new assessment is under development and further information will be available in IRISTrack.

6 April 2012

IRIS posts 2 new Literature Searches for public comment
IRIS announced the availability of literature searches for Acetaldehyde (CAS No. 75-07-0) and 1,2,3-Trimethlybenzene (CAS No. 526-73-8) and ask the public for any additional scientific information on health effects that may result from exposure to these chemical substances. [Federal Register Notice April 6, 2012]

8 March 2012

Update on Ramazzini Institute data in IRIS assessments
EPA announced an update on the use of data from an Italy-based lab, known as the Ramazzini Institute or RI. This decision will impact IRIS assessments under development for methanol, MTBE and ETBE. The draft assessment for acrylonitrile is not affected, as EPA relied on data from sources other than the Ramazzini Institute to complete this draft assessment.

2 March 2012

IRIS Toxicological Review of Biphenyl (External Peer Review Meeting Announcement) 
EPA announced an external peer review meeting for the review of the draft report, IRIS Toxicological Review of Biphenyl (External Review Draft) to be held on April 3, 2012 in Arlington, VA. [Federal Register March 2, 2011]

28 February 2012

[Update] New Schedule for IRIS Hexavalent Chromium Assessment Announced
EPA has announced a new schedule for completing the IRIS hexavalent chromium assessment, which can be found in IRIS Track (IRISTrack - hexavalent chromium). Based on the recommendations of the external peer review panel, which met in May 2011 to review the draft IRIS assessment for hexavalent chromium (oral exposure only), EPA will consider the results of recently and soon to be completed peer-reviewed primary research on the chemical before finalizing the IRIS assessment. The oral assessment will be revised to address the peer review comments and combined with the inhalation assessment, which is currently in draft development. EPA anticipates that the draft assessment for hexavalent chromium (oral and inhalation) will be released for public comment and external peer review in 2013.

21 February 2012

IRIS Final Assessment of Tetrahydrofuran
EPA announced the release of the final IRIS Summary for Tetrahydrofuran and a new accompanying Toxicological Review (PDF) (207 pp) which have been added to the IRIS website. The Interagency Science Discussion Draft of the Tetrahydrofuran IRIS assessment was also released.

17 February 2012

IRIS Final Assessment of Dioxin (Volume 1)
EPA announced the release of the final IRIS Summary for 2,3,7,8-Tetrachlorodibenzo-p-dioxin and a new accompanying Support Document which have been added to the IRIS Web site. The Interagency Science Discussion Draft of the 2,3,7,8-Tetrachlorodibenzo-p-dioxin IRIS assessment was also released.
[More information on Dioxin can be found on the EPA consumer fact sheet on the Dioxin Science Assessment.]

13 February 2012

IRIS Toxicological Review of 1,4-Dioxane (External Peer Review Meeting Announcement) 
EPA announced an external peer review meeting for the review of the draft report, IRIS Toxicological Review of 1,4-Dioxane (Inhalation) (External Review Draft) to be held on March 19, 2012 in Morrisville, NC. [Federal Register February 13, 2011]

10 February 2012

IRIS Final Assessment of Perchloroethylene
EPA announced the release of the final IRIS Summary for Tetrachloroethylene (Perchloroethylene) and a new accompanying Toxicological Review (PDF) (1,077 pp) which have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Tetrachloroethylene (Perchloroethylene) IRIS assessment was also released.
[More information on PERC can be found on the EPA fact sheet on Tetrachloroethylene/Perchloroethylene]

06 February 2012

IRIS Toxicological Review of Vanadium Pentoxide (External Peer Review Meeting Announcement)
EPA announced that an independent public peer review meeting for the draft IRIS Toxicological Review of Vanadium Pentoxide has been scheduled for March 7, 2012 in Arlington, VA. [Federal Register February 6, 2011]

03 January 2012

SAB Review of IRIS Tox Review of Libby Amphibole Asbestos (External Review Draft Meeting Announcement)
EPA announced a public face-to-face meeting of an SAB Panel to review EPA's draft Toxicological Review of Libby Amphibole Asbestos (August 2011). The meeting was held February 6 - 8, 2012 in Alexandria, VA. [Federal Register Notice December 23, 2011].

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18 November 2011

A new Summary for Dichloromethane and a new accompanying Toxicological Review (PDF) (567 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Dichloromethane IRIS assessment has also been released.

18 November 2011

Request for Nominations of Candidates to the EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee for advice on the review of IRIS Toxicological Reviews, Federal Register Nov 18, 2011

The SAB Staff Office is seeking nominations of experts to serve on the SAB Chemical Assessment Advisory Committee to provide advice regarding Toxicological Reviews of environmental chemicals available on EPA's Integrated Risk Information System (IRIS). Candidates should have knowledge in human health risk assessment and expertise in a range of disciplines including, but not limited to: public health; epidemiology; toxicology; modeling; biostatistics; and risk assessment.

Members of the SAB and its subcommittees constitute a distinguished body of non-EPA scientists, engineers, economists, and social scientists that are nationally and internationally-recognized experts in their respective fields from academia, industry, state, and Tribal governments, research institutes, and non-governmental organizations. Members of SAB committees are appointed by the EPA Administrator for a period of three years. The deadline for nominations closes Jan 6, 2012.

17 November 2011

IRIS Toxicological Review of n-Butanol (External Review Draft) Extension of Public Comment Period

EPA has announced that they have reopened the public comment period for the review of the IRIS Toxicological Review of n-Butanol (External Review Draft) (originally announced in an August 31, 2011 Federal Register Notice until December 7, 2011. [Federal Register Notice Nov 16, 2011]

14 November 2011

IRIS Toxicological Review of Vanadium Pentoxide (External Review Draft) Extension of Public Comment Period & Listening Session Announcement

EPA has announced an extension of the public comment period for the review of the IRIS Toxicological Review of Vanadium Pentoxide (External Review Draft) (originally announced in a September 30, 2011 Federal Register Notice) to December 29, 2011. In addition, EPA has rescheduled the listening session to December 8, 2011. [Federal Register Notice Nov 9, 2011]

26 October 2011

External Peer Review Comments available on the Toxicological Review of Methanol (non-cancer)

On July 22, 2011, an external peer review panel meeting was hosted by an independent contractor on the draft Toxicological Review of Methanol (non-cancer): In Support of the Summary Information in the Integrated Risk Information System (IRIS). Completing this review, a final report of the comments from the workshop were collected and is now available.

30 September 2011

A new Summary for Trichloroacetic acid and a new accompanying Toxicological Review (PDF) (270 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Trichloroacetic acid IRIS assessment has also been released.

30 September 2011

IRIS Toxicological Review of Vanadium Pentoxide (External Review Draft Availability Listening Session Announcement)

EPA announces the release of the draft IRIS Toxicological Review of Vanadium Pentoxide for a 60-day public review and comment period. The Interagency Science Consultation Draft of the Vanadium Pentoxide IRIS assessment has also been released. The deadline for comments is November 29, 2011. [Federal Register Sept 30, 2011]

30 September 2011

IRIS Toxicological Review of Biphenyl (External Review Draft Availability & Listening Session Announcement)

EPA announces the release of the draft IRIS Toxicological Review of Biphenyl for a 60-day public review and comment period. In addition, EPA has also announced that a public listening session will be held on November 16, 2011 in Arlington, VA. The Interagency Science Consultation Draft of the Biphenyl IRIS assessment has also been released. The deadline for comments is November 29, 2011. [Federal Register Sept 30, 2011]

28 September 2011

An updated Summary for Trichloroethylene and a new accompanying Toxicological Review have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Trichloroethylene IRIS assessment has also been released.

23 September 2011

A new Summary for Hexachloroethane and a new accompanying Toxicological Review (PDF)(200 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Hexachloroethane IRIS assessment has also been released.

15 September 2011

IRIS Toxicological Review of n-Butanol (External Review Draft) Extension of Public Comment Period & Listening Session Announcement

EPA has announced an extension of the public comment period for the review of the IRIS Toxicological Review of n-Butanol (External Review Draft) (originally announced in an August 31, 2011 Federal Register Notice) to November 7, 2011. In addition, EPA has rescheduled the listening session to October 26, 2011. [Federal Register Notice Sep 15, 2011]

09 September 2011

IRIS Toxicological Review of 1,4-Dioxane (Inhalation) (External Review Draft Availability & Listening Session Announcement)

EPA has released the Toxicological Review of 1,4-Dioxane (Inhalation) (External Review Draft) for public review and comment. EPA is extending the close of the public comment period, announced in the August 31, 2011, Federal Register Notice to November 15, 2011. This changes will be announced in a Federal Register Notice shortly. The Interagency Science Consultation Draft of the 1,4-Dioxane (Inhalation) IRIS assessment is temporarily unavailable.

08 September 2011

IRIS Toxicological Review of n-Butanol (External Review Draft Availability & Listening Session Announcement)

EPA has released the Toxicological Review of n-Butanol (External Review Draft) for public review and comment. EPA is extending the close of the public comment period, announced in the August 31, 2011, Federal Register Notice to November 7, 2011. The listening session, also announced in the August 31, 2011, Federal Register Notice, has been rescheduled to October 26, 2011. These changes will be announced in a Federal Register Notice shortly. The Interagency Science Consultation Draft of the n-butanol IRIS assessment has also been released.

31 August 2011

Extension of Public Comment Period for IRIS Toxicological Review of Acrylonitrile (External Review Draft)

EPA announces the extension of the public comment period to September 28, 2011 for the draft IRIS Toxicological Review of Acrylonitrile (External Review Draft). [Federal Register Notice Aug 31, 2011]

31 August 2011

IRIS Toxicological Review of 1,4-Dioxane (External Review Draft Availability & Listening Session Announcement)

EPA announced the draft IRIS Toxicological Review of 1,4-Dioxane in an August 31, 2011 Federal Register Notice, but the document and charge were temporarily unavailable. In addition, EPA also announced that a public listening session will be held on October 18, 2011 in Arlington, VA. [Federal Register Notice Aug 31, 2011]

31 August 2011

IRIS Toxicological Review of n-Butanol (External Review Draft Availability & Listening Session Announcement)

EPA announced the draft IRIS Toxicological Review of n-Butanol in an August 31, 2011 Federal Register Notice, but the document and charge were temporarily unavailable. In addition, EPA also announced that a public listening session will be held in Arlington, VA. [Federal Register Notice Aug 31, 2011]

29 August 2011

Press Release: EPA Announces Schedule for the Dioxin Assessment & availability of the SAB Final Report

EPA announced the release of the SAB final report of EPA's draft, "Reanalysis of Key Issues Related to Dioxin Toxicity & Response to NAS Comments" which states that the criteria for study selection were applied in a scientifically sound manner and were well described. Additionally, EPA announced its decision to split the dioxin assessment into 2 portions: 1) Non-cancer assessment, which EPA will complete by the end of Jan 2012. When finalized, the non-cancer assessment will mark a significant milestone for EPA because it is the first time the Agency has set an oral reference dose for dioxin; and a 2) Cancer assessment, which EPA will address as expeditiously as possible after the non-cancer assessment is posted to the IRIS database. [Press Release Aug 29, 2011]

25 August 2011

IRIS Toxicological Review of Libby Amphibole Asbestos (External Review Draft Availability & Listening Session Announcement)

EPA announces the release of the draft IRIS Toxicological Review of Libby Amphibole Asbestos for a 60-day public review and comment period. In addition, EPA has also announced that a public listening session will be held on October 6, 2011. The Interagency Science Consultation Draft of the Libby Amphibole Asbestos IRIS assessment has also been released. [Federal Register Notice Aug 25, 2011]

21 July 2011

External Peer Review Comments available on the Toxicological Review of Hexavalent Chromium

On May 12, 2011, an external peer review panel meeting was hosted by an independent contractor on the draft Toxicological Review of Hexavalent Chromium: In Support of the Summary Information in the Integrated Risk Information System (IRIS). Completing this review, a final report of the comments from the workshop were collected and is now available.

13 July 2011

A new Summary for Urea and a new accompanying Toxicological Review (PDF) (97 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Urea IRIS assessment has also been released.

12 July 2011

EPA Strengthens IRIS Assessment Process

EPA announces a plan to further strengthen and streamline its IRIS assessment development process based on recommendations made by the National Academy of Sciences in an April 2011 evaluation. [Press Release Jul 12, 2011]

30 June 2011

IRIS Toxicological Review of Acrylonitrile (External Review Draft Availability & Listening Session Announcement)

EPA announces the release of the draft IRIS Toxicological Review of Acrylonitrile for a 60-day public review and comment period. In addition, EPA has also announced that a public listening session will be held on August 10, 2011 in Arlington, VA. The Interagency Science Consultation Draft of the Acrylonitrile IRIS assessment has also been released. [Federal Register Notice Jun 30, 2011]

22 June 2011

Workshop on the Review of Methanol (non-cancer) in support of IRIS announced along with an addendum to the draft toxicological review document

EPA is announcing an addendum to the IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft) document. Included with this announcement is a 14-day public comment period for review of the addendum, and the details for an upcoming public workshop to be held on July 22, 2011 in Durham, NC. The deadline for comments is July 6, 2011. [Federal Register Jun 22, 2011]

18 April 2011

IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft Availability & Listening Session Announcement)

EPA announces the release of the draft IRIS Toxicological Review of Methanol (Non-Cancer) for a 60-day public review and comment period. In addition, EPA has also announced that a public listening session will be held on May 26, 2011 in Arlington, VA. [Federal Register April 18, 2011 ]

12 April 2011

IRIS Toxicological Review of Hexavalent Chromium Peer Review Workshop

EPA announces that Eastern Research Group, Inc., an EPA contractor for external scientific peer review, will convene an independent panel of experts and organize and conduct an external peer review workshop to review the draft human health assessment titled, "Toxicological Review of

Hexavalent Chromium: In Support of Summary Information on the Integrated Risk Information System (IRIS)" on May 12, 2011. [Federal Register April 12, 2011]

11 April 2011

EPA Announces Plan of Action to Address Four IRIS Assessments

EPA announced its plan to address the four draft Integrated Risk Information System (IRIS) assessments that were placed on hold in June 2010, pending a review of some of the underlying studies relied on in the assessments, per a report written by the National Toxicology Program (NTP), a program administered by the National Institute of Environmental Health Sciences (NIEHS). The four assessments are methanol, methyl tertiary-butyl ether (MTBE), ethyl tertiary- butyl ether (ETBE), and acrylonitrile. EPA and NIEHS decided to jointly sponsor an independent Pathology Working Group (PWG) review, in cooperation with the Ramazzini Institute, of selected studies. The review has begun and will continue over the next several months. [Press Release April 11, 2011]

24 March 2011

The Reference Dose for Chloropyrifos was removed from the IRIS database.

11 March 2011

Availability of Literature Searches for Four IRIS Assessments

EPA is announcing the availability of literature searches for four IRIS assessments and is requesting scientific information on health effects that may result from exposure to these chemical substances. [Federal Register March 11, 2011 ]

20 January 2011

External Peer Review Comments available on the Toxicological Review of Urea On December 13, 2010, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Urea: In Support of the Summary Information in the Integrated Risk Information System (IRIS). Completing this review, a final report of the comments from the workshop were collected and is now available.

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13 December 2010

Availability of Literature Searches for Four IRIS Assessments

EPA is announcing the availability of literature searches for four IRIS assessments and is requesting scientific information on health effects that may result from exposure to these chemical substances. [Federal Register Dec 10, 2010]

9 December 2010

External Peer Review Comments available on the Toxicological Review of Hexachloroethane (HCE)

On September 21, 2010, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Hexachloroethane (HCE): In Support of the Summary Information in the Integrated Risk Information System (IRIS). Completing this review, a final report of the comments from the workshop were collected and is now available.

15 November 2010

Workshop on Cumulative Mixtures Risk of 6 Selected Phthalates in support of IRIS Announced

EPA is announcing an independent external scientific peer workshop to: (1) Review the recommendations for evaluation of the cumulative mixtures risk of phthalates as set forth in the National Academies of Science (NAS) report "Phthalates and Cumulative Risk Assessment: The Tasks Ahead" (2008); and (2) propose additional methods and approaches, not already captured in the 2008 NAS report, that may facilitate the assessment of risk(s) associated with exposure to cumulative mixtures of the six selected phthalates. [Federal Register November 15, 2010]

10 November 2010

IRIS Toxicological Review of Urea (External Peer Review Meeting Announcement) EPA announces an external peer review meeting for the review of the draft report, IRIS Toxicological Review of Urea (External Review Draft) to be hosted on December 13, 2010 via teleconference. [Federal Register November 10, 2010]

10 November 2010

IRIS Toxicological Review of Hexavalent Chromium (External Review Draft - Extension Notice)

EPA is announcing an extension of the public comment period for the IRIS Toxicological Review of Hexavalent Chromium (External Review Draft) for an additional 30 days. The new deadline for comments is December 29, 2010. [Federal Register November 10, 2010]

3 November 2010

External Peer Review Comments available on the Toxicological Review of Dichloromethane (Methylene Chloride)

On September 23, 2010, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Dichloromethane (Methylene Chloride): In Support of the Summary Information in the Integrated Risk Information System (IRIS). Completing this review, a final report of the comments from the workshop were collected and is now available.

18 October 2010

IRIS Nomination Form Announced

EPA is soliciting public nominations for chemical substances for its 2011 agenda for the IRIS Program. EPA invites the public to submit nominations for substances to be considered for an assessment or reassessment in its IRIS Program using the form provided on the IRIS Web site. Details are provided in the federal register notice, deadline for comments is December 17, 2010. [Federal Register October 18, 2010]

30 September 2010

IRIS Toxicological Review of the Chromium VI (Hexavalent) Assessment (External Review Draft Availability)

EPA announces the release of the draft document, Toxicological Review of Chromium VI Assessment: In Support of Summary Information on the Integrated Risk Information System (IRIS) for a 90-day public review and comment period. Following the review period, EPA has also announced that a public listening session will be held on November 18, 2010. The Interagency Science Consultation Draft of the Chromium VI (Hexavalent) IRIS assessment has also been released. [Federal Register September 30, 2010]

30 September 2010

A new Summary for Chloroprene and a new accompanying Toxicological Review (PDF) (303 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Chloroprene IRIS assessment has also been released.

30 September 2010

An updated Summary for Cis-1,2-dichloroethlyene and a new accompanying Toxicological Review (PDF) (174 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Cis-1,2-dichloroethlyene IRIS assessment has also been released.

30 September 2010

An updated Summary for Pentachlorophenol and a new accompanying Toxicological Review (PDF) (288 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Pentachlorophenol IRIS assessment has also been released.

30 September 2010

An updated Summary for 1,1,2,2-Tetrachloroethane and a new accompanying Toxicological Review (PDF) (153 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the 1,1,2,2-Tetrachloroethane IRIS assessment has also been released.

30 September 2010

An updated Summary for Trans-1,2-dichloroethylene and a new accompanying Toxicological Review (PDF) (174 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Trans-1,2-dichloroethylene IRIS assessment has also been released.

28 September 2010

IRIS Toxicological Review of Urea (External Review Draft Availability & Listening Session Announcement)

EPA announces the release of the draft document, Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk Information System (IRIS) for a 60 day public review and comment period. Following the review period, EPA has also announced that a public listening session will be held on November 16, 2010. The Interagency Science Consultation Draft of the Urea IRIS assessment has also been released.

[Federal Register September 28, 2010]

28 September 2010

An updated Summary for Hydrogen Cyanide and Cyanide Salts and a new accompanying Toxicological Review (PDF) (153 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Hydrogen Cyanide and Cyanide Salts IRIS assessment has also been released.

17 August 2010

IRIS Toxicological Review of Dichloromethane (External Peer Review Meeting Announcement)

EPA announces an external peer review meeting for the review of the draft report, IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (External Review Draft) to be hosted on September 23, 2010 in Bethesda, MD. [Federal Register August 17, 2010]

11 August 2010

An updated Summary for 1,4-Dioxane and a new accompanying Toxicological Review (PDF) (320 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the 1,4-Dioxane IRIS assessment has also been released.

2 August 2010

IRIS Toxicological Review of Hexachloroethane (External Peer Review Meeting Announcement)

EPA announces an external peer review meeting for the review of the draft report, IRIS Toxicological Review of Hexachloroethane (External Review Draft) to be hosted on September 21, 2010 in Arlington, VA.

[Federal Register August 2, 2010]

23 June 2010

Extension of Public Comment Period: Draft EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments

Since the release of the draft dioxin reanalysis report, EPA has received several requests for additional time to submit comments. In response to these requests, EPA is extending the public comment period until September 20, 2010 (making this a 120-day public comment period). This draft report responds to the key recommendations and comments included in the National Academy of Sciences (NAS) 2006 report. In addition, it includes new analyses on potential human effects that may result from exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). [Federal Register June 23, 2010]

15 June 2010

EPA Places Four IRIS Assessments on Hold Pending Review

EPA is announcing a hold on four of its ongoing IRIS (Integrated Risk Information System) assessments pending a review of some of the underlying studies used in the assessments. EPA is holding these assessments due to a report from the National Toxicology Program (NTP) that outlines a recent review of a research study completed by the Ramazzini Institute, a lab in Italy that conducts animal testing to evaluate the potential cancer-causing effects of chemicals. The report discusses findings from a recent assessment by NTP pathologists of an animal study on methanol. NTP’s report recommends that further pathology reviews be carried out to resolve differences of opinion between NTP scientists and the Ramazzini Institute in the diagnoses of certain cancers reported in the study. [Press Release June 15, 2010]

14 June 2010

Dioxin Reanalysis Draft Report: Public Listening Session Announcement

EPA is announcing a listening session to be held on July 9, 2010. This draft assessment, EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments in Support of Summary Information on the Integrated Risk Information System (IRIS) was previously provided for public viewing and comment. [Federal Register June 14, 2010]

2 June 2010

IRIS Toxicological Review of Formaldehyde-Inhalation Assessment (External Review Draft Availability & Listening Session Announcement)

EPA announces the release of the draft document, Toxicological Review of Formaldehyde- Inhalation Assessment: In Support of Summary Information on the Integrated Risk Information System (IRIS) for a 90-day public review and comment period. EPA has also announced that a public listening session will be held on July 27, 2010. The Interagency Science Consultation Draft of the Formaldehyde IRIS assessment has also been released. [Federal Register June 2, 2010] [Press Release June 1, 2010]

26 May 2010

External Peer Review Comments available on the Toxicological Review of Mirex On April 1, 2003, the Toxicological Review of Mirex and supporting documents were released for external review. Comments from the public review and external peer review meeting of this report were consolidated and the report is now available.

24 May 2010

EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (External Peer Review Meeting Announcement)

EPA's Science Advisory Board (SAB) Staff is announcing a teleconference (6/24) and a face-to- face meeting (7/13-15) of the SAB Dioxin Review Panel to review the draft report, EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments, released late last week. [Federal Register May 24, 2010]

21 May 2010

EPA’s Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (External Review Draft Availability)

EPA announces the release of the draft document, EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments for a 90 day public review and comment period. SAB will announce by Federal Register the dates and details of the public external review meeting. The Interagency Science Consultation Draft of the dioxin reanalysis has also been released. [Federal Register May 21, 2010]

13 May 2010

IRIS Toxicological Review of Hexachloroethane (External Review Draft Availability & Listening Session Announcement)

EPA announces the release of the draft document, Toxicological Review of Hexachloroethane: In Support of Summary Information on the Integrated Risk Information System (IRIS) for a 60 day public review and comment period. Following the review period, EPA has also announced that a public listening session will be held on June 16, 2010. The Interagency Science Consultation Draft of the hexachloroethane IRIS assessment has also been released. [Federal Register May 13, 2010]

7 May 2010

Availability of Literature Searches for Four IRIS Assessments

EPA is announcing the availability of literature searches for four IRIS assessments and is requesting scientific information on health effects that may result from exposure to these chemical substances. [Federal Register May 7, 2010]

31 March 2010

IRIS Toxicological Review of Trichloroethylene (External Review Draft) Public Meeting Announcement

EPA's SAB announces two public meetings of the SAB Trichloroethylene (TCE) Review Panel: a teleconference (4/20/10) and a face-to-face meeting (5/10-12) to review EPA's Toxicological Review of Trichloroethylene (External Review Draft). [Federal Register March 31, 2010]

31 March 2010

IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (External Review Draft Availability & Listening Session Announcement)

EPA announces the release of the draft document, Toxicological Review of Dichloromethane (Methylene Chloride): In Support of the Summary Information in the Integrated Risk Information System (IRIS), for a 60 day public review and comment period. Following the review period, EPA has also announced that a public listening session will be held on May 11, 2010. The Interagency Science Consultation Draft of the dichloromethane IRIS assessment has also been released. [Federal Register March 31, 2010]

31 March 2010

An updated Summary for Ethylene glycol monobutyl ether (EGBE) and a new accompanying Toxicological Review (PDF) (206 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the EGBE IRIS assessment has also been released.

31 March 2010

An updated Summary for Carbon Tetrachloride and a new accompanying Toxicological Review (PDF) (473 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the carbon tetrachloride IRIS assessment has also been released.

22 March 2010

An updated Summary for Acrylamide and a new accompanying Toxicological Review (PDF) (459 pp) have been added to the IRIS Web site. The Interagency Science Discussion Draft of the Acrylamide IRIS assessment has also been released.

19 March 2010

External Peer Review Comments available on the Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE)

On January 26, 2010, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Ethyl Tertiary Butyl Ether: In Support of the Summary Information in the Integrated Risk Information System (IRIS). Completing this review, a final report of the comments from the workshop were collected and is now available.

26 February 2010

Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft Availability & Listening Session Announcement)

EPA announces the release of the draft document, Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft), for a 60-day public review and comment period. Following the review period, EPA has also announced that a public listening session will be held on April 7, 2010. The interagency comments and the interagency draft of the PAH draft report has also been released. [Federal Register February 26, 2010]

26 February 2010

External Peer Review Comments available on the Toxicological Review of 1,1,2,2-tetrachloroethane

On January 27, 2010, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of 1,1,2,2-Tetrachloroethane: In Support of the Summary Information in the Integrated Risk Information System (IRIS). Completing this review, a final report of the comments from the workshop were collected and is now available.

19 February 2010

IRIS Toxicological Review of Inorganic Arsenic (Cancer) (External Review Draft) EPA announces the release of the draft document, Toxicological Review of Inorganic Arsenic (Cancer): In Support of the Summary Information in the Integrated Risk Information System (IRIS), for a 60 day public review and comment period. The Interagency Science Consultation Draft of the arsenic IRIS assessment has also been released. [Federal Register February 19, 2010]

4 February 2010

External Peer Review Comments available on the Toxicological Review of Chloroprene

On January 6, 2010, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Chloroprene (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and is now available.

25 January 2010

External Peer Review Comments available on the Toxicological Review of cis- and trans-1,2-dichloroethylene

On December 17, 2009, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of cis- and trans-1,2-dichloroethylene (External Review

Draft). Completing this review, a final report of the comments from the workshop were collected and is now available.

21 January 2010

External Peer Review Comments available on the Toxicological Review of Hydrogen Cyanide and Cyanide Salts

On December 14, 2009, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Hydrogen Cyanide and Cyanide Salts (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and is now available.

19 January 2010

External Peer Review Comments available on the Toxicological Review of Trichloroacetic Acid

On December 10, 2009, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Trichloroacetic Acid (External Review Draft).

Completing this review, a final report of the comments from the workshop were collected and is now available.

12 January 2010

IRIS Toxicological Review of Methanol: Public Listening Session Announcement EPA is announcing a listening session to be held on February 23, 2010, during the public comment period for the draft document entitled, Toxicological Review of Methanol: In Support of Summary Information on the Integrated Risk Information System (IRIS). The Interagency Science Consultation Draft of the methanol IRIS assessment has also been released. [Federal Register January 12, 2010]

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22 December 2009

IRIS Toxicological Review of Ethyl Tertiary Butyl Ether: Notice of Peer-Review Workshop

EPA announces the details of an external peer-review workshop to be held on January 26, 2010. This draft assessment, Toxicological Review of Ethyl Tertiary Butyl Ether: In Support of Summary Information on the Integrated Risk Information System (IRIS) was previously provided for public viewing and comment. [Federal Register December 22, 2009]

21 December 2009

IRIS Toxicological Review of Trichloroethylene: Public Listening Session Announcement

EPA is announcing a listening session to be held on January 26, 2010, during the public comment period for the draft document entitled, Toxicological Review of Trichloroethylene: In Support of Summary Information on the Integrated Risk Information System (IRIS). [Federal Register December 21, 2009; more details can be found a prior released December 11, 2009 Federal Register Notice.]

17 December 2009

IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane: External Peer-Review Panel Workshop Announcement

EPA announces the details of an external peer review workshop to be held on January 27, 2010. This draft assessment, Toxicological Review of 1,1,2,2-Tetrachloroethane: In Support of Summary Information on the Integrated Risk Information System (IRIS) was previously provided for public viewing and comment. [Federal Register December 21, 2009]

1 December 2009

Notice of IRIS Toxicological Review of Chloroprene: External Peer-Review Workshop EPA will will convene an independent panel of experts and organize and conduct an external peer-review workshop to review the external review draft document titled, "Toxicological

Review of Chloroprene: In Support of Summary Information in the Integrated Risk Information System (IRIS)" [Federal Register December 1, 2009]

10 November 2009

Notice of IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts: External Peer-Review Workshop

EPA will convene an independent panel of experts and organize and conduct an external peer review workshop to review the external review draft document titled, "Toxicological Review of

Hydrogen Cyanide and Cyanide Salts (External Review Draft)." [Federal Register November 10, 2009]

10 November 2009

Notice of IRIS Toxicological Review of Trichloroacetic Acid: External Peer-Review Workshop EPA will convene an independent panel of experts and organize and conduct an external peer review workshop to review the external review draft document titled, "Toxicological Review of Trichloroacetic Acid (External Review Draft)." [Federal Register November 10, 2009]

10 November 2009

Notice of IRIS Toxicological Review of Cis-and Trans-1,2-Dichloroethylene: External Peer-Review Workshop

EPA will convene an independent panel of experts and organize and conduct an external peer review workshop to review the external review draft document titled, "Toxicological Review of Cis-and Trans-1,2-Dichloroethylene (External Review Draft)." [Federal Register November 10, 2009]

5 November 2009

Notice of IRIS Toxicological Review of Choroprene: Listening Session

EPA is announcing a listening session to be held on November 23, 2009, during the public comment period for the external review draft document entitled, "Toxicological Review of Choroprene: In Support of Summary Information on the Integrated Risk Information System (IRIS)." [Federal Register November 5, 2009]

3 November 2009

IRIS Toxicological Review of Trichloroethylene (External Review Draft)

EPA announces the release of the draft Toxicological Review of Trichloroethylene (TCE) for a 90-day public review and comment period. Additionally, as per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, Interagency Science Consultation Draft and the interagency draft of the trichloroethylene IRIS assessment have also been released. [Federal Register November 3, 2009]

2 November 2009

Announcement of Availability of Literature Searches for IRIS Assessments

EPA is announcing the availability of additional literature searches on the IRIS Web site [Federal Register November 2, 2009]

21 October 2009

External Peer Review Comments available on the Toxicological Review of ethylene glycol monobutyl ether (EGBE)

On April 25, 2008, the Toxicological Review of ethylene glycol monobutyl ether (EGBE) was released for external review. Comments from the first and second rounds of this review were consolidated and reports are now available.

21 October 2009

External Peer Review Comments available on the Toxicological Review of Pentachlorophenol

On August 4, 2009, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Pentachlorophenol (External Review Draft).

Completing this review, a final report of the comments from the workshop were collected and is now available.

14 October 2009

IRIS Toxicological Review of Cerium Oxide and Cerium Compounds (Interagency Science Consultation Draft)

EPA has released the draft documents and comments from the Interagency Science Discussion of the Toxicological Review of Cerium Oxide and Cerium Compounds. As per the new IRISprocess, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the Cerium Oxide and Cerium Compounds IRIS assessment have now been posted on the EPA Web site.

14 October 2009

IRIS Toxicological Review of Trichloroacetic Acid (Interagency Science Consultation Draft)

EPA has released the draft documents and comments from the Interagency Science Discussion of the Toxicological Review of Trichloroacetic Acid. As per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the Trichloroacetic Acid IRIS assessment have now been posted on the EPA Web site.

14 October 2009

IRIS Toxicological Review of Chlordecone (Interagency Science Consultation Draft)

EPA has released the draft documents and comments from the Interagency Science Discussion of the Toxicological Review of Chlordecone. As per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the Chlordecone IRIS assessment have now been posted on the EPA Web site.

14 October 2009

IRIS Toxicological Review of 2-Hexanone (Interagency Science Consultation Draft)

EPA has released the draft documents and comments from the Interagency Science Discussion of the Toxicological Review of 2-Hexanone. As per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the 2-Hexanone IRIS assessment have now been posted on the EPA Web site.

14 October 2009

IRIS Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Consultation Draft)

EPA has released the draft documents and comments from the Interagency Science Discussion of the Toxicological Review of 1,2,3-Trichloropropane. As per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the 1,2,3- Trichloropropane IRIS assessment have now been posted on the EPA Web site.

14 October 2009

IRIS Toxicological Review of Cis-and Trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)

EPA has released the draft documents and comments from the Interagency Science Discussion of the Toxicological Review of Cis-and Trans-1,2-Dichloroethylene. As per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the Cis-and Trans-1,2-Dichloroethylene IRIS assessment have now been posted on the EPA Web site.

30 September 2009

A new Summary for Thallium (I), soluble salts and accompanying Toxicological Review (PDF) (163 pp) have been added to the IRIS Web site. This assessment replaces the assessments for the following related substances:

• Thallium acetate
• Thallium carbonate
• Thallium chloride
• Thallium nitrate
• Thallium (I) sulfate

In addition, Thallic oxide has been renamed and replaced by Thallium oxide, for which an updated Summary is available. An updated Summary for Thallium selenite is also available. A new Toxicological Review (PDF) (163 pp) is available for both Thallium oxide and Thallium selenite.

30 September 2009

A new Summary for Bromobenzene and accompanying Toxicological Review (PDF) (123 pp) have been added to the IRIS Web site.

30 September 2009

An updated Summary for 1,2,3-Trichloropropane and a new accompanying Toxicological Review (PDF) (247 pp) have been added to the IRIS Web site.

29 September 2009

A new Summary for Cerium Oxide and Cerium Compounds and accompanying Toxicological Review (PDF) (118 pp) have been added to the IRIS Web site.

29 September 2009

Notice for the Toxicological Review of Chloroprene: External Peer Review Draft

EPA is announcing a public comment period to review the draft document titled, "Toxicological Review of Chloroprene: In Support of Summary Information on the Integrated Risk Information System (IRIS) (External Review Draft)." [Federal Register September 29, 2009]

25 September 2009

A new Summary for 2-Hexanone and accompanying Toxicological Review (PDF) (136 pp) have been added to the IRIS Web site.

24 September 2009

Notice for the Toxicological Review of Trichloroacetic Acid: External Peer Review Draft & Listening Session

EPA is announcing a public comment period to review the draft document titled, "Toxicological Review of Trichloroacetic Acid: In Support of Summary Information on the Integrated Risk Information System (IRIS) (External Review Draft)." EPA is also announcing a public listening session to be held on November 4, 2009. [Federal Register September 24, 2009]

24 September 2009

Notice for the Toxicological Review of Cis-and Trans-1,2-Dichloroethylene: External Peer Review Draft & Listening Session

EPA is announcing a public comment period to review the draft document titled, "Toxicological Review of Cis-and Trans-1,2-Dichloroethylene: In Support of Summary Information on the

Integrated Risk Information System (IRIS) (External Review Draft)." EPA is also announcing a public listening session to be held on October 19, 2009. [Federal Register September 24, 2009]

24 September 2009

Notice for the Toxicological Review of 1,1,2,2-Tetrachloroethane: External Peer Review Draft & Listening Session

EPA is announcing a public comment period to review the draft document titled, "Toxicological Review of 1,1,2,2-Tetrachloroethane: In Support of Summary Information on the Integrated Risk Information System (IRIS) (External Review Draft)." EPA is also announcing a public listening session to be held on October 14, 2009. [Federal Register September 24, 2009]

23 September 2009

Notice for the Toxicological Review of Ethyl Tertiary Butyl Ether: Listening Session Announcement

EPA is announcing a listening session to be held on October 7, 2009, for the external review draft document entitled, "Toxicological Review of Ethyl Tertiary Butyl Ether: In Support of Summary Information on the Integrated Risk Information System (IRIS)." [Federal Register September 23, 2009]

23 September 2009

Notice for the Toxicological Review of Hydrogen Cyanide and Cyanide Salts: External Peer Review Draft & Listening Session

EPA's IRIS Program is announcing a public comment period to review the draft document titled, "Toxicological Review of Hydrogen Cyanide and Cyanide Salts (External Review Draft)." EPA is also announcing a public listening session to be held on October 27, 2009. [Federal Register September 23, 2009]

22 September 2009

A new Summary for Chlordecone (Kepone) and accompanying Toxicological Review (PDF) (183 pp) have been added to the IRIS Web site.

As per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, Interagency Science Consultation Draft and the interagency draft of the chlordecone (kepone) IRIS assessment will be available on the website on or before October 14, 2009.

19 August 2009

NCEA Policy and Procedures for Conducting IRIS Peer Reviews

EPA released an updated policy and procedure guidance for conducting IRIS Peer Reviews which discusses the issue of conflict of interest and and appearance of bias or lack of impartiality when a peer review panel is being formed.

6 July 2009

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of Halogenated Platinum Salts and Platinum Compounds

On May 21, 2009, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Halogenated Platinum Salts and Platinum Compounds (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and is now available.

29 June 2009

Notice of IRIS Toxicological Review of Pentachlorophenol: External Peer Review Meeting EPA will convene an independent panel of experts and organize and conduct an external peer review workshop to review the external review draft document titled, "Toxicological Review of Pentachlorophenol (External Review Draft)." [Federal Register June 29, 2009]

9 June 2009

Notice for the Toxicological Review of 1,4-Dioxane: Listening Session & External Peer Review Workshop Announcements

EPA is announcing a public listening session to be held on Monday, July 6, 2009 and an external peer review workshop to be held on August 17, 2009, during the public comment period for the draft document entitled, "Toxicological Review of 1,4-Dioxane: In Support of Summary Information on the Integrated Risk Information System (IRIS)." [Federal Register June 9, 2009]

9 June 2009

Notice for the Toxicological Review of Pentachlorophenol: Listening Session Announcement EPA is announcing a public listening session to be held on Wednesday, June 24, 2009, for the external review draft document entitled, "Toxicological Review of Pentachlorophenol: In Support of Summary Information on the Integrated Risk Information System (IRIS)." [Federal Register June 9, 2009]

21 May 2009

Notice of the IRIS Program Process Update (2009)

EPA announces reforms to the agency's Integrated Risk Information System (IRIS) that will revitalize the program and ensure its scientific quality, integrity, transparency and timeliness. [Press Release May 21, 2009]

7 May 2009

Notice of the release of the IRIS Toxicological Review of 1,4-Dioxane

EPA's IRIS Program is announcing a public comment period to review the draft document titled, "Toxicological Review of 1,4-Dioxane (External Review Draft)." [Federal Register May 7, 2009]

7 May 2009

Notice of the release of the IRIS Toxicological Review of Pentachlorophenol

EPA's IRIS Program is announcing a public comment period to review the draft document titled, "Toxicological Review of Pentachlorophenol (External Review Draft)." [Federal Register May 7, 2009]

27 April 2009

Notice of IRIS Toxicological Review of Halogenated Platinum Salts and Platinum Compounds: External Peer Review Meeting

EPA will convene an independent panel of experts and organize and conduct an external peer review workshop to review the external review draft document titled, "Toxicological Review of Halogenated Platinum Salts and Platinum Compounds (External Review Draft)." [Federal Register April 27, 2009]

24 March 2009

Notice for the Toxicological Review of Tetrachloroethylene (Perchloroethylene): Third External Peer Review Meeting

EPA is announcing a third independent external peer review to be hosted by the National Academy of Sciences on April 2-3, 2009, for the draft document entitled, "Toxicological Review of Tetrachloroethylene (Perchloroethylene): In Support of Summary Information on the Integrated Risk Information System (IRIS)".

9 March 2009

Notice for the Toxicological Review of Halogenated Platinum Salts and Platinum Compounds: Listening Session Announcement

EPA is announcing a public listening session to be held on Wednesday, March 25, 2009, for the external review draft document entitled, "Toxicological Review of Halogenated Platinum Salts and Platinum Compounds: In Support of Summary Information on the Integrated Risk Information System (IRIS)." [Federal Register March 9, 2009]

6 February 2009

An updated Summary for Nitrobenzene and accompanying Toxicological Review for Nitrobenzene (PDF) (250 pp) have been added to the IRIS Database.

5 February 2009

Notice of the release of the IRIS Toxicological Review of Halogenated Platinum Salts and Platinum Compounds

EPA's IRIS Program is announcing a public comment period to review the draft document titled, "Toxicological Review of Halogenated Platinum Salts and Platinum Compounds (External Review Draft)." [Federal Register February 5, 2009]

1 January 2009

Notice for the Toxicological Review of Tetrachloroethylene (Perchloroethylene): Second External Peer Review Meeting

EPA is announcing a second independent external peer review to be hosted by the National Academy of Sciences on Jan 29-30, 2009, for the draft document entitled, "Toxicological Review of Tetrachloroethylene (Perchloroethylene): In Support of Summary Information on the Integrated Risk Information System (IRIS)".

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17 November 2008

Consolidated Comments on the External Peer Review posted for Carbon Tetrachloride

On May 21, 2008, the Toxicological Review of Carbon Tetrachloride was released for external review. Completing this review, a final report of the comments from the public comment period and external review meeting were collected, and the report is now available.

16 October 2008

Notice for the Toxicological Review of Tetrachloroethylene (Perchloroethylene): External Peer Review Meeting

EPA is announcing an independent external peer review to be hosted by the National Academy of Sciences on November 13, 2008, for the draft document entitled, "Toxicological Review of Tetrachloroethylene (Perchloroethylene): In Support of Summary Information on the Integrated Risk Information System (IRIS)". [Federal Register October 16, 2008]

2 October 2008

Notice for the Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE): Listening Session Announcement

EPA is announcing a listening session to be held on Friday, October 10, 2008, for the external review draft document entitled, "Toxicological Review of Ethylene Glycol Mono Butyl Ether (EGBE): In Support of Summaiy Information on the Integrated Risk Information System (IRIS)." [Federal Register October 1, 2008]

30 September 2008

A new Summary for Propionaldehyde and accompanying Toxicological Review (PDF) (77 pp) have been added to the IRIS Web site.

25 September 2008

Notice for the Toxicological Review of Ethylene Glycol Mono-Butyl Ether: External Peer Review Workshop

EPA will convene an independent panel of experts and organize and conduct an external peer review workshop to review the external review draft document titled, "Toxicological Review of Ethylene Glycol Mono Butyl Ether (EGBE): In Support of Summary Information on the Integrated Risk Information System (IRIS)". [Federal Register September 25, 2008]

9 September 2008

Notice for the Toxicological Review of Carbon Tetrachloride: External Peer Review Meeting

EPA announces an independent External Peer Review Meeting to be hosted on October 14, 2008, for the draft document entitled, "Toxicological Review of Carbon Tetrachloride: In Support of Summary Information on the Integrated Risk Information System (IRIS)". [Federal Register September 9, 2008]

2 September 2008

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of Propionaldehyde

On May 29, 2008, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Propionaldehyde (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

14 August 2008

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of Beryllium

On July 16, 2008, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Beryllium (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

13 August 2008

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of Chlordecone

On April 10, 2008, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Chlordecone (Kepone) (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

12 August 2008

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of Cerium

On July 8, 2008, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Cerium Oxide and Cerium Compounds (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

29 July 2008

Notice for the Toxicological Review of Tetrachloroethylene (Perchloroethylene): Listening Session

EPA announces a listening session to be hosted on August 18, 2008, for the draft document entitled, "Toxicological Review of Tetrachloroethylene (Perchloroethylene): In Support of Summary Information on the Integrated Risk Information System (IRIS)". [Federal Register July 29, 2008]

24 July 2008

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of 2-Hexanone

On May 22, 2008, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of 2-Hexanone (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

30 June 2008

New and Updated IRIS Assessments Available

• A new Summary for 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) and accompanying Toxicological Review (PDF) (85 pp) have been added to the IRIS Web site.
• A new Summary for 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) and accompanying Toxicological Review (PDF) (128 pp) have been added to the IRIS Web site.
• A new Summary for 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) and accompanying Toxicological Review (PDF) (66 pp) have been added to the IRIS Web site.
• An updated Summary for 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209) and accompanying Toxicological Review (PDF) (126 pp) have been added to the IRIS Web site.

26 June 2008

Notice of the release of Toxicological Review of Tetrachloroethylene (Perchloroethylene) EPA's IRIS Program is announcing a public comment period to review the draft document titled, 'Toxicological Review of Carbon Tetrachloroethylene (Perchloroethylene) (External Review Draft).' [Federal Register June 26, 2008]

24 June 2008

Notice for the Toxicological Review of Carbon Tetrachloride: Listening Session

EPA announces a listening session to be hosted on July 16, 2008, for the draft document entitled, "Toxicological Review of Carbon Tetrachloride: In Support of Summary Information on the Integrated Risk Information System (IRIS)". [Federal Register June 24, 2008]

4 June 2008

Notice for the Toxicological Review of Beryllium: Listening Session

EPA announces a listening session to be hosted on June 27, 2008, for the draft document entitled, "Toxicological Review of Beryllium: In Support of Summary Information on the Integrated Risk Information System (IRIS)". [Federal Register June 4, 2008]

3 June 2008

Notice for the Toxicological Review of Cerium Oxide: Listening Session

EPA announces the first "listening session" (per the new IRIS Process 2008 Update) to be hosted on June 25, 2008, for the draft document entitled, "Toxicological Review of Cerium Oxide and Cerium Compounds: In Support of Summary Information on the Integrated Risk Information System (IRIS)". [Federal Register June 3, 2008]

21 May 2008

Notice of the release of Toxicological Review of Carbon Tetrachloride

EPA's IRIS Program is announcing a public comment period to review the draft document titled, 'Toxicological Review of Carbon Tetrachloride (External Review Draft).' [Federal Register May 21, 2008]

12 May 2008

Notice of the release of Toxicological Review of Beryllium and External Peer Review Panel Workshop Announcement

EPA's IRIS Program is announcing a public comment period and an external peer review panel meeting to review the draft document titled, 'Toxicological Review of Beryllium (External Review Draft)' with the release of an updated cancer assessment. [Federal Register May 12, 2008]

6 May 2008

Notice of the release of Toxicological Review of Cerium Oxide and Cerium Compounds

EPA's IRIS Program is announcing a public comment period and an external peer review panel meeting to review the draft document titled, 'Toxicological Review of Cerium Oxide and Cerium Compounds (External Review Draft).' [Federal Register May 6, 2008]

2 May 2008

IRIS Toxicological Review of Propionaldehyde -- External Peer Review Panel Workshop Announcement

EPA's IRIS Program is announcing an external peer review panel meeting to review the draft document titled, 'Toxicological Review of Propionaldehyde (External Review Draft).' [Federal Register May 2, 2008]

25 April 2008

Notice of the availability of Literature Searches for Manganese, 12,4-Trimethylbenzene, and 1,3,5-Trimethylbenzene

EPA announces IRIS announces the availability of literature searches for manganese, 12,4- trimethylbenzene, and 1,3,5-trimethylbenzene. [Federal Register April 25, 2008]

25 April 2008

Notice of the release of Toxicological Review of Ethylene Glycol mono-Butyl Ether (EGBE)

EPA's IRIS Program is announcing a public comment period and an external peer review panel meeting to review the draft document titled, 'Toxicological Review of EGBE (External Review Draft).' [Federal Register April 25, 2008]

23 April 2008

IRIS Toxicological Review of 2-Hexanone -- External Peer Review Panel Workshop Announcement

EPA's IRIS Program is announcing an external peer review panel meeting to review the draft document titled, 'Toxicological Review of 2-hexanone (External Review Draft).' [Federal Register April 23, 2008]

16 April 2008

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of 1,2,3-Trichloropropane

On February 20, 2008, an external peer review panel workshop was hosted by an independent contractor for the Toxicological Review of 1,2,3-Trichloropropane (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

16 April 2008

Final Report on the Development of an Analytic Approach to Determine How Environmental Protection Agency’s Integrated Risk Information System (IRIS) Is Used By Non EPA Decision Makers

EPA is announcing the release of a final contractor report titled, Development of an Analytic Approach to Determine How Environmental Protection Agency’s Integrated Risk Information System (IRIS) Is Used By Non EPA Decision Makers. This contractor report analyzed how IRIS is used outside of the EPA, who these IRIS users are, and how well their needs are being met.

10 April 2008

EPA has announced an update to the current IRIS Process as described on the IRIS Process (2008 Update)

8 April 2008

Notice of the announcement for the External Peer Review Panel Meeting for the Toxicological Review of Thallium and Compounds

EPA's IRIS Program is announcing an external peer review panel meeting to review the draft document titled, 'Toxicological Review of Thallium and Compounds (External Review Draft).' [Federal Register April 8, 2008]

5 March 2008

Notice of the release of Toxicological Review of Propionaldehyde

EPA's IRIS Program is announcing a public comment period and an external peer review panel meeting to review the draft document titled, 'Toxicological Review of Propionaldehyde (External Review Draft).' [Federal Register March 5, 2008]

28 February 2008

Notice of the release of Toxicological Review of 2-Hexanone

EPA's IRIS Program is announcing a public comment period to review the draft document titled, 'Toxicological Review of 2-Hexanone (External Review Draft).' [Federal Register March 3, 2008]

15 February 2008

Notice of the release of Toxicological Review of Thallium

EPA's IRIS Program is announcing a public comment period to review the draft document titled, 'Toxicological Review of Thallium (External Review Draft).' [Federal Register February 15, 2008]

1 February 2008

Notice of the announcement for the External Peer Review Panel Meeting for the Toxicological Review of Acrylamide

EPA's IRIS Program is announcing an external peer review panel meeting to review the draft document titled, 'Toxicological Review of Acrylamide (External Review Draft).' [Federal Register February 1, 2008]

24 January 2008

Notice of the release of Toxicological Review of Chlordecone (Kepone)

EPA's IRIS Program is announcing a public comment period to review the draft document titled, 'Toxicological Review of Chlordecone (Kepone) (External Review Draft).' [Federal Register January 24, 2008]

18 January 2008

Notice of the announcement for the External Peer Review Panel Meeting for the Toxicological Review of 1,2,3-Trichloropropane (TCP)

EPA's IRIS Program is announcing an external peer review panel meeting to review the draft document titled, 'Toxicological Review of 1,2,3-Trichloropropane (External Review Draft).' [Federal Register January 18, 2008]

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28 December 2007

Notice of the release of Toxicological Review of Acrylamide.

EPA's IRIS Program is announcing a public comment period to review the final draft document titled, 'Draft Toxicological Review of Acrylamide: In Support of Summary Information on the Integrated Risk Information System (IRIS).' [Federal Register December 28, 2007].

21 December 2007

2008 IRIS Program Agenda Announced

EPA announces the IRIS 2008 agenda and requests scientific information on health effects that may result from exposure to the chemical substances on the agenda, including assessments that EPA is starting this year. [Federal Register: December 21, 2007 (Volume 72, Number 245)]

20 December 2007

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of Tetrahydrofuran.

On November 1, 2007, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Tetrahydrofuran (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

5 December 2007

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of Bromobenzene.

On June 14, 2007, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Bromobenzene (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

16 November 2007

Notice of the release of Toxicological Review of 1,2,3-Trichloropropane.

EPA's IRIS Program is announcing a public comment period to review the draft document titled, 'Toxicological Review of 1,2,3-Trichloropropane (External Review Draft).' [Federal Register November 16, 2007].

28 September 2007

The Summary of 1,1,1-Trichloroethane has been revised and an updated Toxicological Review (PDF) (237 pp) has been added to the IRIS Web site.

20 August 2007

Notice of the release of Toxicological Review of Tetrahydrofuran (THF) and notice of the External Peer Review Panel Meeting.

EPA's IRIS Program is announcing a public comment period and an external peer review panel meeting to review the draft document titled, 'Toxicological Review of Tetrahydrofuran (External Review Draft).' [Federal Register August 20, 2007].

03 August 2007

External Peer Review Comments available on the Toxicological Review of Nitrobenzene.

On May 15, 2007, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Nitrobenzene (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

31 July 2007

The Summary of 2,2,4-Trimethylpentane has been revised and an updated Toxicological Review (PDF) (43 pp) has been added to the IRIS Web site.

14 June 2007

Notice of the release of the Toxicological Review of Bromobenzene and notice of the External Peer Review Panel Meeting.

EPA's IRIS Program is announcing a public comment period and an external peer review panel meeting to review the draft document titled, 'Toxicological Review of Bromobenzene (External Review Draft)'. [Federal Register Notice June 14, 2007]

5 June 2007

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of 1,1,1-Trichloroethane.

On April 20, 2007, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of 1,1,1-Trichloroethane (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

13 April 2007

External Peer Review Panel Meeting Comments posted on the IRIS Toxicological Review Document of 2,2,4-Trimethylpentane.

On February 28, 2007, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of 2,2,4-Trimethylpentane (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and are now available.

4 April 2007

External Peer Review Panel Meeting Comments posted on the 4 polybrominated diphenyl ethers (PBDE) Toxicological Reviews.

On February 22, 2007, an external peer review panel workshop was hosted by an independent contractor on the PBDE Documents [tetraBDE (BDE-47), pentaBDE (BDE-99), hexaBDE (BDE-153), and decaBDE (BDE-209)]. Completing this review, a final report of the comments from the workshop were collected and are now available.

29 March 2007

External Peer Review Panel Meeting on IRIS Toxicological Review Document for Nitrobenzene.

EPA''s IRIS Program is announcing that an external peer review panel meeting to review the draft document entitled, “Toxicological Review of Nitrobenzene.” The Toxicological Review was published in the Federal Register March 29, 2007 [FRL: 8293-6; FDMS Docket ID: EPA- HQ-ORD-2007-0241].

28 February 2007

External Review Meeting on the document, Toxicological Review of 2,2,4-Trimethylpentane (Feb 28).

EPA is hosting an external peer review panel meeting on February 28, 2007 to review the draft document titled, Toxicological Review of 2,2,4-Trimethylpentane: In Support of Summary Information on the Integrated Risk Information System (IRIS) (NCEA-S-2202), related to the human health assessment for 2,2,4-trimethylpentane. Following the External Peer Review, the final assessment will be posted in the IRIS database.

27 February 2007

Notice of the release of the Toxicological Review of 1,1,1-Trichloroethane and notice of the External Peer Review Panel Meeting.

The EPA is announcing a public comment period and an external peer review panel meeting to review the draft document titled,'Toxicological Review of 1,1,1-Trichloroethane (External Review Draft)'. [Federal Register Notice February 27, 2007]

25 January 2007

The IRIS Web site recently underwent an upgrade to the latest EPA template (version 3.2.1), except for the Multiple Substance Reports, QuickView Summaries, and the Search Results pages which will soon be converted to the new template style. For more details about the EPA Template 3.2.1, visit EPAFiles: Web Design.

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On this page:

2006 | 2005 | 2004 | 2003 | 2002

29 December 2006

Notice of the release of the Toxicological Review for 2,2,4-Trimethylpentane and notice of the External Peer Review Panel Meeting.

The EPA is announcing a public comment period and an external peer review panel meeting to review the draft document titled,'Toxicological Review of 2,2,4-Trimethylpentane: In Support of Summary Information on the Integrated Risk Information System (IRIS)' (NCEA-S-2202), related to the human health assessment for 2,2,4- trimethylpentane. [Federal Register Notice December 29, 2006]

22 December 2006

IRIS Request for Chemical Substance nominations for the IRIS 2007 program agenda

EPA is soliciting public nominations for substances for its 2007 agenda. EPA invites the public to submit nominations for substances to be considered for an assessment or reassessment in its IRIS Program. Nominations must be submitted within 30 days of the publication of this notice. The 30-day period begins December 22, 2006 and ends January 22, 2007. [Federal Register: December 22, 2006 (Volume 71, Number 246)]

22 December 2006

External Peer Review Panel Meeting on IRIS Toxicological Review Documents for Polybrominated Diphenyl Ethers.

EPA's IRIS Program is announcing that an external peer review panel meeting to review the draft documents entitled, "Toxicological Review of TetraBDE (BDE-47): In Support of Summary Information in the Integrated Risk Information System (IRIS)" (NCEA-S-2537); "Toxicological Review of PentaBDE (BDE-99): In Support of Summary Information in the Integrated Risk Information System (IRIS)" (NCEA-S-2538); "Toxicological Review of HexaBDE (BDE-153): In Support of Summary Information in the Integrated Risk Information System (IRIS)" (NCEA- S-2539); and "Toxicological Review of DecaBDE (BDE-209): In Support of Summary Information in the Integrated Risk Information System (IRIS)" (NCEA-S-2540). The documents were published in the Federal Register December 22, 2006 [FR Notice: Volume 71, Number 246; FDMS Docket ID: EPA-HQ-ORD-2006-0838].

20 December 2006

Final Report on the External Peer Review for the IRIS Assessment of 1,4- Dichlorobenzene

This document is the final report for the 2006 external peer review for the IRIS Assessment of 1,4-Dichlorobenzene (inhalation cancer assessment and RfC), prepared by the U.S. Environmental Protection Agency (EPA), Center for Public Health and Environmental Assessment (CPHEA) (formerly known as the National Center for Environmental Assessment (NCEA)), for the Integrated Risk Information System (IRIS). A panel of external peer reviewers met to discuss their responses to the charge questions on November 3, 2006. This document contains the final written comments of the external peer reviewers.

12 October 2006

Dichlorobenzenes and Ethylene Oxide Updates

EPA is releasing by Federal Register Notices two new IRIS Reviews: the Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS) [FR Notice], and the Evaluation of the Carcinogenicity of Ethylene Oxide [FR Notice]

28 September 2006

IRIS Literature Screening Verification

As part of the FR notice (69 FR 5971) issued on February 9, 2004, announcing the annual IRIS agenda, EPA stated that it would use findings from the recent IRIS literature screening level review project as the basis for a systematic update of the IRIS database. The purpose of EPA's screening level review was to reach a preliminary determination regarding the need for a full reassessment. That determination was needed based on an evaluation of new health effects literature that could potentially result in significant changes to existing toxicity values or cancer weight-of-evidence designations. The FR notice stated that EPA would begin performing more in-depth reviews of the extant health literature to confirm results from the literature screening. The IRIS summaries have been updated to confirm that existing assessments are current for the substances that were found to be without significant new health effects information that could result in a change to the existing data in IRIS.

Also, the FR notice requested submission of scientific information from the public to confirm the results of the literature screening review. Confirmatory statements were added on September 19, 2004, June 22, 2005, August 15, 2005 and July 5, 2006 to a total of 56 IRIS Summaries. Since then, another 10 confirmations have been completed for 3,3'-dichlorobenzidine, p-bromodiphenyl ether, tribromochloromethane, benzotrichloride, brominated dibenzofurans, 4,4'-methylene bis(N,N'-dimethyl)aniline, bromate, quinoline, diethyl-p-nitrophenylphosphate, and 1,1,1,2-tetrachloroethane. These confirmations will be added to the IRIS Summaries on 09/28/2006. The results of the screening project were added to the IRIS database beginning in 2003 and continue as an ongoing project.

27 September 2006

Release for Public Review of the Health Assessment Document for the Carcinogenicity of Ethylene Oxide

EPA's IRIS Program is announcing that a 30-day public comment period for the draft document titled, "Evaluation of the Carcinogenicity of Ethylene Oxide" (EPA/635/R-06/003) was published in the Federal Register (09/22/2006) [E-docket No.: EPA-HQ-ORD 2006- 0756]

18 August 2006

Final Report on the External Peer Review for the IRIS Reassessment of Dibutyl Phthalate

This document is the final report for the 2006 external peer review for the IRIS Reassessment of Dibutyl Phthalate, prepared by the U.S. Environmental Protection Agency (EPA), Center for Public Health and Environmental Assessment (CPHEA) (formerly known as the National Center for Environmental Assessment (NCEA)), for the Integrated Risk Information System (IRIS). A panel of external peer reviewers met to discuss their responses to the charge questions on July 28, 2006. This document contains the final written comments of the external peer reviewers.

11 August 2006

Notice of the External Peer Review Panel Meeting on the Toxicological Review for 1,4- Dichlorobenzene

EPA's IRIS Program is announcing that an extension of the public comment period and rescheduling of the external peer review panel teleconference to review the draft document entitled, "Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS)" (EPA/635/R-03/015), was published in the Federal Register on August 11, 2006 [FDMS Docket ID: EPA-HQ-ORD-2004-0002].

13 July 2006

Notice of the External Peer Review Panel Meeting on the Toxicological Review for 1,4- Dichlorobenzene

EPA's IRIS Program is announcing that an external peer review panel meeting to review the draft document entitled, "Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS)" was published in the Federal Register July 11, 2006 [FDMS Docket ID: EPA-HQ-ORD-2004-0002].

05 July 2006

IRIS Literature Screen Verification

The IRIS Program has added statements to certain existing IRIS Summaries confirming that the health effects information upon which the assessment was based is still current. This is to follow up on our February 9, 2004 FR notice (69 FR 5971) announcing the annual IRIS agenda. In that notice, EPA announced that we would use findings from our recent IRIS literature screening project (the results of which were added to IRIS beginning in 2003) as the basis for a systematic update of the IRIS database. We explained that we would begin performing a more in-depth review of the extant health literature to confirm results from the literature screen. For those substances confirmed to be without new health effects information likely to change an existing assessment, we stated that we would update IRIS Summaries to indicate this finding.

Also, in the FR notice we sought submission of scientific information from the public to confirm the results of the literature screen review. Confirmatory statements were added on September 19, 2004, June 22, 2005, and August 15, 2005 to a total of 48 IRIS Summaries. Confirmatory statements for 8 additional substances have been added to IRIS Summaries for methyl methacrylate, nickel refinery dust, 1,2-diphenylhydrazine, tetrachlorocyclopentadiene, trichlorocyclopentadiene, ammonium methacrylate, chlorocyclopentadiene, and t-butylchloride on 07/05/2006. This will be an on-going project.

27 June 2006

Notice of the External Peer Review Panel Meeting on the Toxicological Review for Dibutyl Phthalate

EPA's IRIS Program is announcing that an external peer review panel meeting to review the draft document entitled, "Toxicological Review of Dibutyl Phthalate (Di-n-Butyl Phthalate): In Support of Summary Information on the Integrated Risk Information System (IRIS)" (NCEA-S- 1755) was published in the Federal Register June 27, 2006 [FDMS Docket ID: EPA-HQ-ORD- 2006-0500].

22 May 2006

2006 Corrected IRIS Program Agenda Announced

EPA's announcement of the IRIS 2006 program agenda, with a corrected list of substances, and request for scientific information on human health effects that may result from exposure to substances was published in the May 19, 2006 Federal Register Notice

31 January 2006

The Summary of Phosgene has been revised and an updated Toxicological Review (PDF) (102 pp) has been added to the IRIS Web site.

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23 December 2005

The Summary of n-Hexane has been revised and an updated Toxicological Review (PDF) (210 pp) has been added to the IRIS Web site.

23 September 2005

The Summary of Toluene has been revised and an updated Toxicological Review (PDF) (179 pp) has been added to the IRIS Web site.

26 August 2005

Final Report for the 2005 Peer Consultation Workshop on Research Needs Related to the IRIS Draft Toxicological Review of Naphthalene.

This document is the final report for the 2005 peer consultation workshop to seek expert opinion on research needs related to the mode of action of the inhalation carcinogenicity of naphthalene. A panel of expert participants met to discuss their responses to the charge questions on April 7, 2005. This report is a summary of the main points of presentations and highlights discussions among the participants.

15 August 2005

IRIS Literature Screen Verification

The IRIS Program added statements to certain existing IRIS Summaries confirming that the health effects information upon which the assessment was based is still current. This is to follow up on our February 9, 2004 FR notice (69 FR 5971) announcing the annual IRIS agenda. In that notice, EPA announced that we would use findings from our recent IRIS literature screening project (the results of which were added to IRIS in 2003) as the basis for a systematic update of the IRIS database. We explained that we would begin performing a more in-depth review of the extant health literature to confirm results from the literature screen. For those substances confirmed to be without new health effects information likely to change an existing assessment, we stated that we would update IRIS Summaries to indicate this finding.

Also, in the FR notice we sought submission of scientific information from the public to confirm the results of the literature screen review. Confirmatory statements for 12 substances have been added to IRIS Summaries. Statements for Chloromethyl methyl ether, Ammonium acetate, Bromochloromethane, Crotonaldehyde, Pentachlorocyclopentadiene, Diethylene glycol dinitrate, p,p'-Dibromodiphenyl ether, Dibromodichloromethane, o-Dinitrobenzene, Acetyl chloride, 1- Chlorobutane and Acetonitrile were added to the respective IRIS summaries on 08/15/2005. This will be an on-going project.

03 August 2005

The Summary of Zinc and Compounds has been revised and an updated Toxicological Review(PDF) (83 pp) has been added to the IRIS Web site.

14 July 2005

The IRIS Program is updating the IRIS Glossary by adopting the revised definitions for the reference dose (RfD) and reference concentration (RfC) to implement the recommendations of the RfD/RfC Technical Panel as provided in the report, "A Review of the Reference Dose and Reference Concentration Processes," EPA/630/P-02/002F (U.S. EPA, 2002).

11 July 2005

The summary for Barium and compounds has been revised, and an updated Toxicological Review (PDF) (87 pp) has been added to the IRIS Web site. The oral reference dose (RfD) was revised in response to a Request for Correction (RFC #2293) (PDF) (77 pp) submitted to EPA. The noncancer inhalation and cancer assessments were not revised.

22 June 2005

IRIS Literature Screen Verification

The IRIS Program added statements to certain existing IRIS Summaries confirming that the health effects information upon which the assessment was based is still current. This is to follow up on our February 9, 2004 FR notice (69 FR 5971) announcing the annual IRIS agenda. In that notice, EPA announced that we would use findings from our recent IRIS literature screening project (the results of which were added to IRIS in 2003) as the basis for a systematic update of the IRIS database. We explained that we would begin performing a more in-depth review of the extant health literature to confirm results from the literature screen. For those substances confirmed to be without new health effects information likely to change an existing assessment, we stated that we would update IRIS Summaries to indicate this finding.

Also, in the FR notice we sought submission of scientific information from the public to confirm the results of the literature screen review. Confirmatory statements for 24 substances have been added to IRIS Summaries. Statements for 2,6-Dimethylphenol, 3,4-Dimethylphenol, beta-Chloronaphthalene, Copper cyanide, Dichlorodifluoromethane, Hexabromobenzene, 1,1-Difluoroethane, 1-Chloro- 1,1-difluoroethane, Phosphoric acid, Propylene glycol monoethyl ether, Triethylene glycol monobutyl ether, and Triethylene glycol monoethyl ether were added on March 3, 2005. Statements for 2,4-Dinitrophenol, Chlorine cyanide, 1,4-Dithiane, Glycidaldehyde, Isopropyl methyl phosphonic acid, m-Dinitrobenzene, Monochloramine, p-Chlorophenyl methyl sulfide, Selenious acid, 1,1-Dichloroethylene, Chlorite (sodium salt), and 2-Chlorobutane were added on June 22, 2005. This will be an on-going project.

31 May 2005

Final Report for the 2005 External Peer Review of the Toxicological Review and IRIS Summary for N-Hexane. This document is the final report for the 2005 external peer review for the IRIS Reassessment of n-hexane, prepared by the U.S. Environmental Protection Agency (EPA), Center for Public Health and Environmental Assessment (CPHEA) (formerly known as the National Center for Environmental Assessment (NCEA)), for the Integrated Risk Information System (IRIS). A panel of external peer reviewers met to discuss their responses to the charge questions on March 30, 2005. This document contains the final written comments of the external peer reviewers.

08 March 2005

Notice of a Peer Consultation Workshop on Research Needs Related to the IRIS Draft Toxicological Review of Naphthalene

Environmental Protection Agency (EPA) is announcing a workshop to seek expert opinion on the research needs related to the mode of action of the inhalation carcinogenicity of naphthalene. EPA will consider the comments and recommendations from the expert panel in determining a future course of action for assessing potential health risks associated with naphthalene exposure. The workshop will begin on April 7, 2005.

07 March 2005

EPA's announcement of IRIS 2005 program agenda and request for scientific information on human health effects that may result from exposure to substances was published in the Federal Register on March 4, 2005 [70 FR 42] (PDF) (5 pp).

18 February 2005

A new summary for Perchlorate and Perchlorate Salts has been added to the IRIS Web site. The summary is based on "Health Implications of Perchlorate Ingestion Exit" by the National Research Council of the National Academies (NRC, 2005).

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10 November 2004

IRIS Chemical Assessment Tracking System is now available!

The IRIS Chemical Assessment Tracking System is a compilation of status reports on EPA's IRIS assessments currently in progress. The Status Report for IRIS Chemical Assessments is viewable on line. This report shows the user where the chemical assessment is in its development.

18 October 2004

Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds National Academy Sciences (NAS) Review Draft

On October 15, 2004, the EPA transmitted to the National Academy of Sciences (NAS) the NAS Review Draft of EPA's Exposure and Human Health Reassessment of 2,3,7,8- Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds, in preparation for the first meeting of the NAS panel scheduled for November 22 and 23, 2004, in Washington, DC. For detailed information on the NAS's dioxin review activity, titled "Review of EPA's Assessment of the Health Implications of Exposure to Dioxins," please visit the NAS website at The National Academies of Sciences Engineering Medicine Exit. This will bring you to a description of the project, a list of the provisional panel, and information about the upcoming meeting.

29 September 2004

IRIS Literature Screen Verification

The IRIS Program is beginning to add statements to certain existing IRIS Summaries confirming that the health effects information upon which the assessment was based is still current. This is to follow up on our February 9, 2004 FR notice (69 FR 5971) announcing the annual IRIS agenda. In that notice, EPA announced that we would use findings from our recent IRIS literature screening project (the results of which were added to IRIS in 2003) as the basis for a systematic update of the IRIS database. We explained that we would begin performing a more in-depth review of the extant health literature to confirm results from the literature screen. For those substances confirmed to be without new health effects information likely to change an existing assessment, we stated that we would update IRIS Summaries to indicate this finding.

Also, in the FR notice we sought submission of scientific information from the public to confirm the results of the literature screen review. The first 12 confirmatory statements have been added to IRIS Summaries for Barium cyanide, Butylphthalyl butylgylcolate, 1,4-Dibromobenzene, 2,3- Dichloropropanol, Ethylphthalyl ethylglycolate, Methyl chlorocarbonate, Selenourea, Silver cyanide, 1,1,2-Trichloropropane, Vernam, Cyanogen bromide, and 1,2,4-Tribromobenzene. This will be an on-going project.

10 September 2004

Final Report on the External Peer Review for the IRIS Reassessment of the Inhalation Carcinogenicity of Naphthalene

This document is the final report for the 2004 external peer review for the IRIS Reassessment of the Inhalation Carcinogenicity of Naphthalene, prepared by the U.S. Environmental Protection Agency (EPA), Center for Public Health and Environmental Assessment (CPHEA) (formerly known as the National Center for Environmental Assessment (NCEA)), for the Integrated Risk Information System (IRIS). A panel of external peer reviewers met to discuss their responses to the charge questions on July 30, 2004. This document contains the final written comments of the external peer reviewers.

16 August 2004

Final Report on the External Peer Review of the U.S. Environmental Protection Agency's Draft Document, "Proposed Oral Reference Dose (Rfd) for Barium and Compounds."

The Final Report on the External Peer Review of the U.S. Environmental Protection Agency's draft document "Proposed Oral Reference Dose (RfD) for Barium and Compounds", contains the external reviewer's responses to the peer review charge and meeting notes from the meetings held June 10, 2004, and July 21, 2004.

05 August 2004

The summary for Boron and compounds has been revised, and a new Toxicological Review (PDF) (144 pp) has been added to the IRIS Web site.

29 July 2004

The summary for 1,2-Dibromoethane has been revised, and a new Toxicological Review (PDF) (240 pp) has been added to the IRIS Web site.

08 July 2004

An updated summary for Lead and compounds (inorganic) has been added to the IRIS Web site.

07 July 2004

External Peer Review Panel Meeting on IRIS Toxicological Review and Summary Documents for Naphthalene

The U.S. EPA is announcing that an external peer review panel meeting to review the inhalation cancer assessment and selected text in the external review draft document entitled, "Toxicological Review of Naphthalene: In Support of Summary Information on the Integrated Risk Information System (IRIS)"(NCEA-S-1707) was published in the Federal Register July 7, 2004 [FRL-7783-2; E-docket No.: ORD-2004-0007]

13 February 2004

Notice of peer review workshop of the external draft document titled, Neurotoxicity of Tetrachloroethylene. The draft document and charge to reviewers are available on the NCEA Web site. The workshop will be held on February 25, 2004. Federal Register notice.

09 February 2004

EPA's 2004 IRIS agenda and request for information was published in the Federal Register on February 9, 2004 [69 FR 5971]. Federal Register notice.

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22 December 2003

A new summary for 2-Methylnaphthalene and accompanying Toxicological Review (PDF) (97 pp) have been added to the IRIS Web site.

3 December 2003

An IRIS search has been updated -- Search by Evidence for Human Carcinogenicity. The updated search allows allows IRIS users to search the IRIS database to identify substances by weight-of-evidence classifications established by EPA using the 1986, 1996, and 1999 Guidelines for Carcinogen Risk Assessment. These guidelines reflect the evolution of the science in this area and the corresponding evolution of the Agency's approach to characterizing weight- of-evidence for human carcinogenicity. To view the search, please go to the IRIS Search page.

21 November 2003

A new search has been added to the IRIS Web site -- Search IRIS by Uncertainty and Modifying Factors. The new search allows IRIS users to search for the composite uncertainty factor values, uncertainty factors and uncertainty factor values, and modifying factor values used to derive RfDs and RfCs. The search will return the identity of the substances for which the selected factors have a selected value or value range. To view the search, please go to the IRIS Search page.

07 November 2003

Screening-Level Literature Review Findings -- General findings of EPA's screening-level review of the recent health effects literature have been added to the "EPA Review" sections of 160 IRIS Summaries. IRIS users may request information about the review methods and results from the IRIS Hotline (hotline.iris@epa.gov) or 202-566-1676.

15 October 2003

The IRIS program support contractor operations will be relocated from the contractor facilities in Greenbelt, MD. This change is described in the Federal Register notice link located in the October 14, 2003 Recent Additions item below. The IRIS Reading Room will also be relocated to this address and visitation is made by appointment only. To schedule a visit call (202) 566- 1676. These changes are scheduled to become effective October 17, 2003. The new IRIS Hotline address, phone number, and fax number will be:

• IRIS Hotline
• c/o EPA Docket Center, Mail Code 28221T EPA-West Building
• 1301 Constitution Avenue, NW Washington, DC 20005
• Phone: (202) 566-1676 Fax: (202) 566-1749
• Visitor/Courier/Fed Ex, UPS, etc., Delivery Address
• EPA West Building
• EPA Docket Center, Room B-102 1301 Constitution Avenue, NW Washington, DC 20004

14 October 2003

Federal Register notice announcing the relocation of IRIS Hotline Operations and Record Center.

26 September 2003

EPA's IRIS Needs Assessment was announced in the Federal Register and is available. IRIS Needs Assessment (PDF) (78 pp).

26 September 2003

The summary for Methyl ethyl ketone has been revised, and a new Toxicological Review (PDF) (152 pp) has been added to the IRIS Web site.

Also, a new summary for Cyclohexane and accompanying Toxicological Review (PDF) (87 pp) have been added to the IRIS Web site.

11 September 2003

The summary for Dichloroacetic acid has been revised, and a new Toxicological Review (PDF) (192 pp) has been added to the IRIS Web site.

13 August 2003

An invitation to nominate new assessments for the Fiscal Year 2004 IRIS Program was published in the Federal Register on August 13, 2003 (Vol. 68, Number 156). An electronic nomination form for submission of substances is located on the Federal Register notice. In addition, this notice highlights 6 substances that were added to the fiscal year 2003 agenda (published in the Federal Register on February 5, 2003) and requests the submission of pertinent scientific information for the development of these health assessments.

31 July 2003

The summary for Acetone has been revised, and a new Toxicological Review (PDF) (85 pp) has been added to the IRIS Web site.

28 July 2003

The summary for Hydrogen Sulfide has been revised, and a new Toxicological Review (PDF) (74 pp) has been added to the IRIS Web site.

03 June 2003

The summary for Acrolein has been revised, and a new Toxicological Review (PDF) (106 pp) has been added to the IRIS Web site.

25 April 2003

The summary for Methyl Isobutyl Ketone (MIBK) has been revised, and a new Toxicological Review (PDF) (68 pp) has been added to the IRIS Web site.

17 April 2003

The summary for Benzene has been revised, and a new Noncancer Effects Toxicological Review (PDF) (180 pp) has been added to the IRIS Web site.

28 February 2003

The summary for Diesel engine exhaust has been revised, and new Support Documents have been added to the IRIS Web site.

21 February 2003

The summary for Xylenes has been revised, and a new Toxicological Review (PDF) (113 pp) has been added to the IRIS Web site.

5 February 2003

EPA's 2003 IRIS agenda and request for information was published in the Federal Register on February 5, 2003 [68 FR 5870].

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03 December 2002

Screening-Level Literature Review Findings -- General findings of EPA's screening-level review of the recent health effects literature have been added to the "EPA Review" sections of IRIS Summaries. Three hundred substances have been screened thus far. IRIS users may request information about the review methods and results from the IRIS Hotline (hotline.iris@epa.gov) or 202-566-1676.

05 November 2002

The summary for 1,3-Butadiene has been revised, and a new Support Document has been added to the IRIS Web site.

02 October 2002

The updated QuickView and Search information for Phenol is available on the IRIS Web site.

30 September 2002

The summary for Phenol has been revised, and a new Toxicological Review for Phenol (PDF) (213 pp) has been added to the IRIS Web site. The QuickView and Search information for Phenol will be updated on October 3, 2002.

13 August 2002

The summary for 1,1-Dichloroethylene has been revised, and a new Toxicological Review for 1,1-Dichloroethylene (PDF) (72 pp) has been added to the IRIS Web site.

26 March 2002

The list of external peer reviewers in the Toxicological Review for Chloroform (PDF) (112 pp) has been corrected.

11 February 2002

Revision histories now note those substances being re-assessed under the IRIS Program.

09 January 2002

EPA's 2002 IRIS agenda and request for information was published in the Federal Register on January 9, 2002 [67 FR 1212]. Federal Register notice.

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On this page:

2001 | 2000 | 1999 | 1998 | 1997

19 October 2001

The summary for Chloroform has been revised, and a new Toxicological Review for Chloroform (PDF) (112 pp) has been added to the IRIS Web site.

27 September 2001

A new IRIS Summary and Toxicological Review for Quinoline have been added to the IRIS Web site.

13 August 2001

The IRIS program support contractor operations have relocated from the EPA's Center for Public Health and Environmental Assessment (CPHEA), formerly known as the National Center for Environmental Assessment (NCEA), in Cincinnati, OH to contractor facilities in Greenbelt, MD. This change is described in the Federal Register notice link located in the 23 July 2001 Recent Additions item below. The IRIS Reading Room has also relocated to this address and visitation is made by appointment only. To schedule a visit call 301-345-2870. The new contractor's address is:  IRIS, c/o ASRC, 6301 Ivy Lane, Suite 300 Greenbelt, MD 20770

31 July 2001

The references for Methylmercury have been corrected.

27 July 2001

The Oral RfD Summary and associated references for Methylmercury have been replaced.

23 July 2001

Two notices were published in the Federal Register concerning IRIS.

• Information on the IRIS Needs Assessment.
• Announcement of the upcoming move of IRIS hotline operations and the availability of the new IRIS Web site redesign.

17 July 2001

A new IRIS Summary and Toxicological Review for Methyl chloride have been added to the IRIS Web site.

05 July 2001

The summary for Hexachlorocyclopentadiene (HCCPD) has been revised, and a new Toxicological Review for Hexachlorocyclopentadiene (HCCPD) has been added to the IRIS Web site.

06 June 2001

A new IRIS Summary and Toxicological Review for Bromate have been added to the IRIS Web site.

01 May 2001

Removed links to Private Sector and Non-Governmental Organizations from the IRIS Links page.

26 February 2001

EPA's 2001 IRIS agenda and request for information was published in the Federal Register February 22, 2001 [66 FR 11165]. Federal Register notice.

14 February 2001

Characterization of Data Variability and Uncertainty: Health Effects Assessments in the Integrated Risk Information System (IRIS) is available on the NCEA Web site. EPA is releasing the final report of an evaluation of IRIS concerning documentation of data variability and uncertainty, in response to a Congressional directive contained in HR 106-379. The final report reflects EPA's Science Advisory Board review.

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12 October 2000

The summaries for Chlorite (sodium salt) and Chlorine dioxide have been revised, and a new Toxicological Review (PDF) (56 pp) for both substances has been added to the IRIS Web site.

26 September 2000

Corrections have been made to the IRIS Summary and Toxicological Review for Vinyl Chloride. See Vinyl Chloride Revision History.

15 September 2000

The summary for Chloral has been revised, and is renamed Chloral hydrate. Also, a new Toxicological Review of Chloral hydrate has been added to the IRIS Web site.

07 August 2000

New IRIS Summary and Toxicological Review for Vinyl chloride have been added to the IRIS Web site.

25 May 2000

The summary for 1,3-Dichloropropene has been revised, and a new Toxicological Review for 1,3-Dichloropropene (PDF) (83 pp) has been added to the IRIS Web site.

17 May 2000

An addendum to EPA's 2000 IRIS agenda and request for information was published in the Federal Register May 17, 2000 [65 FR 31309]. Federal Register notice.

19 January 2000

The summary for benzene has been revised with a new oral carcinogenicity assessment.

12 January 2000

EPA's 2000 IRIS agenda and request for information was published in the Federal Register Jan. 12, 2000 [65 FR 1863]. Federal Register notice.

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30 December 1999

New IRIS Summary and Toxicological Review for Ethylene glycol monobutyl ether (EGBE) have been added to the IRIS Web site.

6 December 1999

In response to user requests, EPA has updated and revised the IRIS Glossary, and added a column to the List of IRIS Substances indicating the date of the last significant revision to each substance file.

3 March 1999

New IRIS Summary and Toxicological Review for Acetonitrile have been added to the IRIS Web site.

21 January 1999

Minor revisions to the IRIS Summary and Toxicological Review (PDF) (87 pp) for Barium and Compounds

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16 December 1998

On November 19, 1998 residual web-conversion dates of 3/1/1997 and 4/1/1997 were removed from the top of individual substance files. These dates will be replaced with correct dates for the last revision for each file. The replacement process will take several months. Readers should consult the Revision History [Section VII] of each substance file for the date of the most recent revision.

10 December 1998

EPA's 1999 IRIS agenda and request for information was published in the Federal Register Dec. 10, 1998 [63 FR 68285]. Federal Register notice.

19 November 1998

The 2 digit dates within the substance files have been updated to 4 digits. Although EPA has certified IRIS as Y2K-compliant, the change to 4-digit years makes the system consistent with other EPA Y2K actions.

16 October 1998

The summary for benzene has been revised with a new inhalation carcinogenicity assessment.

30 September 1998

New IRIS Toxicological Review for Naphthalene (PDF) (116 pp) has been added to the IRIS Web site. This assessment was developed as part of EPA's IRIS Pilot Program.

17 September 1998

New IRIS Summary for Naphthalene has been added to the IRIS Web site. This assessment was developed as part of EPA's IRIS Pilot Program.

3 September 1998

New IRIS Summaries and Toxicological Reviews for Chromium(III) and Chromium(VI) have been added to the IRIS Web site. These assessments were developed as part of EPA's IRIS Pilot Program.

13 July 1998

Stand Alone (Downloadable) IRIS database

This feature is designed for users interested in having a copy of the entire IRIS Web site on their local hard drives. We are making this available in response to the needs of users traveling or with intermittent internet access. More information on the IRIS Stand Alone version.

11 June 1998

"Table of Contents" Feature

A format improvement has been made to all substance files. There is now a short "Table of Contents" at the beginning of each substance file with direct links to individual sections of the file. This enables the user to go directly to various sections [e.g., carcinogenicity section] without scrolling through the entire file.

In addition, there is a new title block design, and all the section headings have been highlighted to improve reading and navigation.

30 April 1998

The support document for 1,3,5-Trinitrobenzene (PDF) (34 pp) was replaced with format corrections.

24 April 1998

A New IRIS Toxicological Review for Beryllium and compounds (PDF) (94 pp) is now available and was also added to the List of Available IRIS Toxicological Reviews Page.

10 April 1998

Discussion has been added to Section II.B.3 of the arsenic file (Additional Comments - Carcinogenicity, Oral Exposure). This is the only change to the arsenic file being made under EPA's IRIS Pilot.

3 April 1998

A new IRIS Summary for Beryllium and compounds has been added to the IRIS Web site.

30 March 1998

A new IRIS Summary for Barium and Compounds and a new IRIS Toxicological Review for Barium and Compounds (PDF) (87 pp) has been added to the IRIS Web site. The List of Available IRIS Toxicological Reviews Page has also been updated.

13 March 1998

The New IRIS Toxicological Review (PDF) (30 pp) for Bentazon (Basagran) is now available and was also added to the List of Available IRIS Toxicological Reviews Page.

12 March 1998

The New IRIS Toxicological Review (PDF) (80 pp) for Methyl methacrylate is now available and was also added to the List of Available IRIS Toxicological Reviews Page.

2 March 1998

New IRIS summaries for Methyl methacrylate and Bentazon were added 2 March 1998. Methyl methacrylate is a substance newly added to IRIS. The Toxicological Reviews for these substances will be added later this month, as will summaries and Toxicological Reviews for barium and beryllium. These files are developed under the IRIS Pilot Project.

23 February 1998

We have been making minor adjustments to files converted on 7 February 1998 that had conversion problems. If you notice any problems with files or navigation in IRIS, please email them to the attention of the Webmaster (Iris.Webmaster@epa.gov). Your comments are always welcome.

7 February 1998

IMPORTANT!

This IRIS Web site and EPA's internal PC-based IRIS2 system have been running in parallel since March 1997. The scientific content of the two systems has been the same during this ramp- up period for the web site. Effective 7 February 1998, this web site is EPA's central location for IRIS. The PC-based IRIS2 system will not be updated after 2 February 1998. We made this change to improve the efficiency and flexibility of the system and speed our delivery of IRIS to you. This web site will be updated continuously as new information is produced for IRIS. Check this "Recent Additions" file frequently for new information.

Several improvements are effective today:

• IRIS Search. The substance files have been converted from .dat to .html format, which allows use of the EPA server's Verity search engine. This allows you to search the entire IRIS data base for search words present in any of the files. The search engine will present a list of links to files that met your search criteria. Once you have opened an individual file, your browser's search engine (e,g., Netscape's "find in file" command under the "edit" menu) can be used to search within that file. By the end of February 1998, you will also have the ability to go from the top of a substance file directly to the RfD, RfC, and carcinogenicity sections. Other search improvements are underway and will be announced here when available. Searching may be unstable in early February while we fine-tune the new capabilities.
• Substance file format conversion. Until now, the substance files were ASCII text files (.DAT format). Some users of Microsoft Internet Explorer and America Online had difficulty reading this format with their browser. All of the substance files are now converted to HTML (.htm format) files. We hope this will eliminate the problems some of our users were encountering.
• Chlordane. The revised chlordane file is now loaded. Note that the companion Toxicological Review for chlordane (PDF) (73 ppF) was loaded December 1997.
• Methylene diphenyl diisocyanates. The revised MDI file and Toxicological Review (PDF) (54 pp) are now loaded.
• "Look and feel." We have enhanced the appearance of the IRIS Home Page and sought to improve navigation within the website.
• One-stroke download. We are working on a quick and easy way for you to download the data base to a hard disk drive for use in your local environment. This is particularly to help users in the field, on the road, and those with intermittent access to the Internet.
• Methyl methacrylate and Bentazon files and Toxicological Reviews are planned for loading later in February.

9 January 1998

IRIS Federal Register Notice of 2 January 1998

The Federal Register published the U.S. Environmental Protection Agency's document, "Integrated Risk Information System (IRIS); Announcement of 1998 Program; Request for Information." This notice provided: "Announcement of IRIS 1998 Program and request for scientific information on chronic health effects of substances."

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30 December 1997

IRIS Pilot Project Toxicological Review Document for Chlordane Available

A new Toxicological Review Document for Chlordane; CASRN 12789-03-6 (PDF) (73 pp) is now available online. This document was developed under the IRIS Pilot Project. An updated IRIS Summary file for the chemical will be loaded on or about 1 February 1998. The List of Substances on IRIS is updated to show the availability of this additional Toxicological Review.

23 December 1997

There are no start-of-the-month file updates for January 1998.

3 December 1997

There are no start-of-the-month file updates for December 1997.

12 November 1997

There are no start-of-the-month file updates for November 1997.

20 October 1997

The information in the previous "IRIS News" page has been combined with this page, and the IRIS News is eliminated as a separate page.

3 October 1997

The summary file for 1,3,5-Trinitrobenzene; CASRN 99-35-4 was updated with a new oral reference dose based on the support document mentioned below. The references in the summary file for Cumene were updated. There are no other substance file updates for October 1997.

18 September 1997 A new Support Document for 1,3,5-Trinitrobenzene; CASRN 99-35-4 is now available online as an Adobe Acrobat PDF file. An updated RfD summary for the chemical will be loaded in the Fall, 1997. The List of Substances on IRIS is updated to show the availability of the Support Document and the Toxicological Reviews.

8 September 1997 The updated IRIS Summary file for Tributyltin oxide is now available online. The updated file was developed under the IRIS Pilot Project. The file for Nitrite; CASRN 14797- 65-0 was updated to correct a concentration reference in Section I.A.2. There are no other substance file updates for September 1997.

Further details:

• Oral RfD Replaced on IRIS: Tributyltin oxide; CASRN 56-35-9 (RfD changed)
• Inhalation RfC Added to IRIS: Tributyltin oxide; CASRN 56-35-9 (RfD changed)
• Carcinogenicity Assessment Added to IRIS: Tributyltin oxide; CASRN 56-35-9 (RfD changed)
• File Revised: Nitrite; CASRN 14797-65-0

13 August 1997

The updated IRIS Summary file for Cumene is now available online. The updated file was developed under the IRIS Pilot Project. There are no other substance file updates for August 1997.

Further details:

• Oral RfD Replaced on IRIS:   Cumene; CASRN 98-82-8 (RfD changed)
• Inhalation RfC Added to IRIS:  Cumene; CASRN 98-82-8
• Carcinogenicity Assessment Added to IRIS: Cumene; CASRN 98-82-8

15 July 1997

IRIS Pilot Project Toxicological Review Documents for Cumene and Tributyltin Oxide (TBTO) Available

The first two toxicological review documents to be developed under the IRIS Pilot Project are available from the new List of Available IRIS Toxicological Reviews page for the substances Cumene and Tributyltin oxide (TBTO). The documents are available as Adobe Acrobat Portable Document Format (PDF) files. These toxicological reviews are the background documents for the upcoming new IRIS Summary files for Cumene (expected mid-August 1997) and TBTO (expected September 1997). The toxicological review documents will also be linked from the new IRIS Summary files when they go online.

The file for 1,2-Dibromoethane; CASRN 106-93-4 was updated to correct a multiplication factor in Section II.C.3. There are no other substance file updates for July 1997.

1 July 1997

Drinking Water Regulations and Health Advisories

Added a link on the IRIS page Links to Other Sources of Environmental Health Information to the US EPA Office of Water web page that provides Drinking Water Regulations and Health Advisories (PDF) (18 pp) information.

26 June 1997

IRIS Pilot Project

EPA has a project underway to improve EPA's efficiency in developing information for IRIS, build Agency-wide consensus, and improve documentation for IRIS. The Pilot process is being tested on 11 chemical assessments. New or revised IRIS summaries and support documents called "Toxicological Reviews" are being developed for:

Arsenic
Bentazon
Beryllium
Chlordane
Chromium
Cumene
Methyl methacrylate
Methylene diphenyl diisocyanate [MDI]
Naphthalene
Tributyltin oxide
Vinyl chloride

New or revised assessment summaries for these substances will be made available on IRIS as they are completed during the Summer and Fall, 1997. Concurrently, Toxicological Reviews will be made available electronically on the IRIS web site.

23 June 1997

Scientific Assistance on the Hotline

A full time toxicologist was added to the Risk Information Hotline in June 1997 to assist users with chemical-specific questions pertaining to assessments listed in IRIS. The toxicologist will also answer questions pertaining to the IRIS Background Documents that describe the rationales and methods used by EPA to derive the information contained in IRIS. The toxicologist can be contacted by calling the U.S. EPA Risk Information Hotline at telephone 1-513-569-7254, or fax to 1-513-569-7159, or email to Risk Information Hotline (RIH.IRIS@epamail.epa.gov).

17 June 1997

A list of available EPA reference documents was added to the IRIS Background Documents page.

5 June 1997

The file for Polychlorinated biphenyls (PCBs); CASRN 1336-36-3 was updated to correct units in Section II.C.3. There are no other substance file updates for June 1997.

12 May 1997

There are no updates to any of the IRIS substance files for May. The list of substances was corrected to include 2,4-Dichlorophenol which had been inadvertently omitted from the list. The revised list links to files for 535 substances.

4 April 1997

The April 1997 monthly update was uploaded. 128 substance files were revised to eliminate obsolete status information. No changes made to scientific content. Revised acronyms and glossary files uploaded. IRIS News page added. As of 1 April 1997, the health advisories and regulatory actions have been removed from IRIS, since it was determined that the most definitive information is available directly from the appropriate EPA Program Office. Copies of the IRIS background documents that describe the rationale and methods used by EPA to derive the information contained in IRIS are available by contacting the U.S. EPA Risk Information Hotline at telephone 1-513-569-7254, or fax to 1-513-569-7159, or email to Risk Information Hotline (RIH.IRIS@epamail.epa.gov).

13 March 1997

Revised substance list to remove substances for which files are not available. The revised list links to files for 534 substances.

11 March 1997

New IRIS Home Page uploaded. Uploading of additional supporting files is ongoing.

10 March 1997

New IRIS chemical files uploaded, current as of 1 March 1997. Regular, monthly uploads of updated files are planned.

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