This Web page includes the Toxicological Review for Tetrachloroethylene (Perchloroethylene) and several supporting documents.

• Toxicological Review of Tetrachloroethylene (PDF) (1,077 pp, 8.91 MB, About PDF)

Critical Studies

Reference: Carcinogencity Study of Tetrachloroethylene by Inhalation in Rats and Mice. Japan Industrial Safety Association. 1993.

• JBRC 03-31-1993 Final
• JBRC 2-yr Part 1 Final
• JBRC 2-yr Part 2 Final
• Histological Findings (Two-Year Studies: Individual)
  • JBRC 2-yr Append Z Part 1_Final
  • JBRC 2-yr Append Z Part 2 Final
  • JBRC 2-yr Append Z Part 3 Final
  • JBRC 2-yr Append Z Part 4 Final
  • JBRC 2-yr Append Z Part 5 Final
  • JBRC 2-yr Append Z Part 6 Final
  • JBRC 2-yr Append Z Part 7 Final

Reference: Perchloroethylene: Multigeneration Inhalation Study in the Rat (Report No: CTL/P/4097). Zeneca Central Toxicology Laboratory. 1994.

• Zeneca Tinston 11-03-1994 Part 1 Final
• Zeneca Tinston 11-03-1994 Part 2 Final (Glossary)
• Individual Animal Data Supplement (4 volumes)
  • Zeneca Vol 1 06-27-1995 Part 1 Final
  • Zeneca Vol 1 06-27-1995 Part 2 Final
  • Zeneca Vol II 06-27-1995 Part 1 Final
  • Zeneca Vol II 06-27-1995 Part 2 Final
  • Zeneca Vol II 06-27-1995 Part 3 Final
  • Zeneca Vol III 06-27-1995 Part 1 Final
  • Zeneca Vol III 06-27-1995 Part 2 Final
  • Zeneca Vol IV 11-03-1994 Part 1 Final
  • Zeneca Vol IV 11-03-1994 Part 2 Final
  • Zeneca Vol IV 11-03-1994 Part 3 Final

Reference: The Influences of Exposure Pattern and Duration on Elimination Kinetics and Exposure Assessment of Tetrachloroethylene in Humans. Graduate School - New Brunswick, Rutgers, The State University of New Jersey. 1997.

• Yeh-Chung Chien 1997 Part 1 Final
• Yeh-Chung Chien 1997 Part 2 Final