In December 2018, the National Academies of Sciences, Engineering, and Medicine (NAS) hosted a workshop on current state-of-the-art methods for performing systematic reviews of mechanistic data in support of chemical assessments. Topic areas of discussion included:
- Approaches and tools to search and screen the literature for mechanistic data,
- Approaches to evaluating the validity of mechanistic studies,
- Methods for assimilating and using mechanistic information to support evidence synthesis and integration, and
- Practical experience with implementing systematic reviews of mechanistic evidence into human health assessments.
The objective of the workshop was to explore relevant strategies and tools that are being developed and used across the systematic review and risk assessment communities to assist the US Environmental Protection Agency (U.S. EPA) with developing guidance on performing systematic reviews of mechanistic data to support the chemical assessments in its Integrated Risk Information System (IRIS) Program.
- Download the presentations, videos and workshop materials, Strategies and Tools for Conducting Systematic Reviews of Mechanistic Data to Support Chemical Assessments
- NAS Workshop Agenda (Dec 10-11, 2018)
A poster session was included at the workshop that had examples demonstrating the application of systematic review approaches to mechanistic data.
Download the EPA Posters
You may need a PDF reader to view some of the files on this page. See EPA’s About PDF page to learn more.- NAS Scientific Poster (Arzuaga) Dec2018 (PDF)(1 pg, 739 K, 12-10-2018)
- NAS Scientific Poster (Druwe) Dec 2018 (PDF)(1 pg, 515 K, 12-10-2018)
- NAS Scientific Poster (Fritz) Dec 2018 (PDF)(1 pg, 2 MB, 12-10-2018)
- NAS Scientific Poster (Nichols) Dec 2018 (PDF)(1 pg, 896 K, 12-10-2018)
- NAS Scientific Poster (Stewart) Dec 2018 (PDF)(1 pg, 740 K, 12-10-2018)