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4th Annual STAR Organotypic Culture Models (OCM) for Predictive Toxicology Research Centers Progress Review

Date and Time

Wednesday 10/16/2019 8:30AM to 5:00PM EDT
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109 TW Alexander Dr
Auditorium C111A-C
Durham, NC 27709


This will be the final STAR meeting with all 4 OCM Centers and their EPA colleagues. The Purpose of this meeting is to review their overall accomplishments, especially as they can be applied towards utilitarian risk assessment purposes. We will also be introduced to the new research projects from the Advancing Actionable Alternatives to Vertebrate Animal Testing for Chemical Safety Assessment RFA. Presentations will allow time for questions and discussion of challenges to the research’s practical applications.

8:15 a.m. Registration
8:30 a.m. Welcome and Introduction
Jeff Frithsen, EPA, Chemical Safety for Systainability Research Program Director
9:00 a.m. Progress and Next Steps in Making Organ-on-chip Technologies Amenable to Toxicity Testing
Shane Hutson, Vanderbilt University, Vanderbil-Pittsburgh Resource for Oganotypic Models for Predictive Toxicology (VPROMPT)
9:40 a.m. Progress and Next Steps in Human Models for Analysis of Pathways
Bill Murphy, University of Wisconsin Madison, Human Models for analysis of Pathways (HMAPs) Center
10:20 a.m. Break
10:55 a.m. Organtypic Cultures and Assessment of AOP's: Importance of Medium Through Put Assays for Reducing Animal Use
Elaine Faustman, University of Washington, Predictive Toxicology Center for Organotypic Cultures and Assessment of AOP's for Engineered Nanomaterials
11:35 a.m. Microphysiological Systems that Fill Data Gaps in Human Health Assessments
Ivan Rusyn, Texas A&M University, Cardiotoxicity Adverse Outcome Pathway: Organotypic Culture MOdel and In-vito-to-in-vivo Exptrapolation for High-throughput Hazard, Dose-response and Variablilty Assessments Center
12:15 p.m. Lunch
1:15 p.m. Update and Challenges to ORD's Virtual Tissue Modeling Efforts
Sid Hunter, Chief of the EPA ORD-Center for Computational Toxicology and Exposure (CCTE), Biomolecular & Computational Toxicology Division (BCTD), Advance Experimental Toxicology Models Branch (AETMB)
1:40 p.m. Translation and Implementation of New Approach Mothodologies
Maureen Gwinn, Division Director, EPA ORD-CCET-BCTD
2:00 p.m. Break
2:15 p.m. Update on ORD's Stem Cell Modeling Efforts
2:45 p.m. Skeletal Teratogenicity of Industrial and Environmental Chemicals Predicted with Human Pluripotent Stem Cells In Vitro
Nochole zurNiden, University of California - Riverside
3:00 p.m. Multiplexed Human Brain Sphere Developmental Neurotoxicity Test for Six Key Events of Neural Development
Lena Smirnova, Johns Hopkins University
3:15 p.m. A Nerovascular Unit on Chip for reducing Animals in Organiphosphate Neurotoxicology
David Cliffel, Vanderbilt University
3:30 p.m. Instumenting Phinotyupic Immunological Responses to Toxicants that Threaten Human Reproduction
Kevin Osteen, Vanderbilt University
3:35 p.m. Reducing the Reliance on Early-life Stage Testing with Relevance to Euryhaline Fishes: Development and Implementation fo In-vitro Assays Predictive of early Life Stage Toxicity and Population-level Effects in Mendia Beryllina
Kaly Major, Post-Doc, Oregon State University
4:00 p.m. Panel Discussion; Remaining Challenges to the Development and Implementation of Alternative Test Methods
OCM Center Investigators and EPA Senior Scientists

Meeting Files
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