Details

Informational Webinar
Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations Applications
Request for Applications (RFA)

Date: Wednesday, Aug. 7, 2019
Time: 2:00 p.m. – 3:30 p.m.

Join us for this informational webinar discussing the application process and required elements for the Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations Applications Request for Applications (RFA)

The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications to advance the development of chemical toxicokinetic tools and approaches for broader applicability during chemical evaluations, with an emphasis on their application within new approach methodology (NAM) frameworks. This RFA is seeking research on development and evaluation of new approaches and/or assays that can be applied in in vitro in to vivo extrapolation (IVIVE) approaches able to inform chemical toxicokinetics.  The proposed research should provide the best available science needed to address them.  The research also will improve the scientific foundation for environmental policy and decision-making related to chemical exposure and risk.

This informational webinar will review the RFA’s research interest and application and review process. Attendees will have opportunity to ask questions from EPA experts.

Webinar Objectives

• Share General Information about the EPA STAR RFA, “Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations Applications” (Project Officer)
• Introduce Research Questions (Project Officer, EPA Technical Experts)
• Learn about the administrative, submission, eligibility and peer review processes (EPA Eligibility, Submission, and Peer Review Officers)
• Questions & Answer Session

RFA Research Areas Questions

1. Development and integration of new assays and approaches.

Research in this area should be aimed at developing new in vitro and/or in silico approaches that can be integrated into toxicokinetic screening approaches or rapid assessment methodologies to improve the accuracy of chemical screening, hazard identification or risk assessment.  New or refined approaches that generate and make use of experimental in vitro data and address a currently unmet need may include, for example:

1. Assays that reproducibly provide measures for challenging chemicals that are a part of the environmental chemical exposure space (for example, volatile, lipophilic, and/or per- and poly-fluorinated chemicals);
2. Assays that measure TK parameters not currently available via in vitro approaches, that may be of relevance to sensitive populations or lifestages
3. Approaches that reproducibly characterize metabolite formation that can be used to support of development of in silico tools to predict metabolism and/or metabolic bioactivation

2. High-throughput approaches applicable to multiple chemicals or chemical classes.

Chemical-specific analytical method development is often a significant bottleneck of the currently used TK assays. Research aimed at developing new methods or techniques that are broadly applicable to multiple chemicals/chemical classes may alleviate the low throughput inherent in the conventionally used targeted mass spectrometry method development.  Examples could include Nuclear Magnetic Resonance (NMR), radioflow, spectrophotometric, or elemental analysis assays. 

Webinar Files

• Toxicokinetics RFA Webinar Slides (PDF)(13 pp, 436 K, 8/14/2019)
• FAQ - Toxicokinetics RFA Webinar (PDF)(2 pp, 109 K, 8/14/2019)