EPA conducted a State-of-the-Science Workshop on Chemically-induced Mouse Lung Tumors: Applications to Human Health Assessments. The purpose of this workshop was to discuss the available data and interpretation of results from studies of mouse bronchiolar-alveolar adenomas and carcinomas (lung tumors) following exposure to chemical agents, and the relevance of such tumors in mice to human cancer risk. Several lines of research have investigated whether or not these types of lung tumors are formed by a mode of action (MOA) which is specific to mice and are relevant to tumor formation or other toxicity in humans.

• Workshop Details
• Workshop Agenda
• Panelists, Speakers and Project Team
• Workshop Materials

Download Materials:

• Session Abstracts: State of the Science Workshop on Chemically-induced Mouse Lung Tumors: Application to Human Health Risk Assessment (PDF)(55 pp, 3 MB)
• Goals and Scope of the Workshop (PDF)(24 pp, 301 K)
• Session 1 Overview (PDF)(4 pp, 312 K)
• Session 1: Approaches to Determining Carcinogenic Risks in Humans (PDF)(19 pp, 488 K)
• Session 1: Epidemiological Studies of Human Lung Cancer (PDF)(22 pp, 1 MB)
• Session 1: Lung Cancer Mortality: Worker Exposed to Styrene, Ethylbenzene, or Naphthalene (PDF)(32 pp, 1 MB)
• Session 1: Human Lung Cancer Pathology and Cellular Biology (PDF)(18 pp, 1 MB)
• Session 2 Overview (PDF)(19 pp, 2 MB)
• Session 2: Comparative Lung Pathology (PDF)(16 pp, 1 MB)
• Session 2: Mouse Lung Tumor Model Considerations (PDF)(22 pp, 5 MB)
• Session 2: Rodent Lung Tumors in NTP Studies (PDF)(25 pp, 3 MB)
• Session 2: Species Difference in Response and Cell of Origin (PDF)(25 pp, 10 MB)
• Session 2: Animal and Human Tumour Site Concordance (PDF)(30 pp, 2 MB)
• Session 3 Overview (PDF)(5 pp, 1 MB)
• Session 3: A Framework for Considering the CYP2F2 MOA Hypothesis & Relevance of Mouse Lung Tumors to Humans (PDF)(7 pp, 693 K)
• Session 3: Hypothesis-Driven MOA Analysis: CYP2F2 (PDF)(24 pp, 853 K)
• Session 3: Pharmacokinetics and Pharmacodynamics of Ethylbenzene (PDF)(16 pp, 1 MB)
• Session 3: Pharmacokinetics and Pharmacodynamics of Naphthalene (PDF)(20 pp, 1 MB)
• Session 3: Pharmacokinetics and Pharmacodynamics of Styrene (PDF)(21 pp, 1 MB)
• Session 3: Related Chemicals: CYP2F2 Substrates & Other Mouse Lung Tumorigens (PDF)(9 pp, 2 MB)
• Session 3: Integration of Cross Cutting Issues (PDF)(4 pp, 76 K)
• Session 4 Overview (PDF)(5 pp, 75 K)
• Session 4: An Overview of the Genotoxicity of Aromatic Hydrocarbons and their Reactive Intermediates (PDF)(13 pp, 376 K)
• Session 4: Mouse Lung Carcinogens, Reactive Metabolites and Toxicity (PDF)(26 pp, 725 K)
• Session 4: Overview of New and Developing Omic Technologies: Assessing Molecular Toxicity and Disease Susceptibility (PDF)(28 pp, 3 MB)
• Session 4: Metabolomics (PDF)(9 pp, 1 MB)